1P-LSD 150 MCG Pellets Product Description

Introduction

1P-LSD, or 1-propionyl-lysergic acid diethylamide, is a synthetic lysergamide and a chemical analog of LSD distinguished by a propionyl group at the nitrogen-1 position. Supplied as 150 microgram pellets, 1P-LSD is designed for precise dosing in research applications. It is mainly used in scientific settings for investigating psychedelic pharmacology, receptor binding, and metabolism. The prodrug nature of 1P-LSD, metabolizing to LSD in vivo, makes it valuable for exploring effects related to serotonergic psychedelic mechanisms.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C23H29N3O2

• Molecular Weight: Approximately 379.5 g/mol

• CAS Number: 2349358-81-0

• IUPAC Name: (6aR,9R)-N,N-diethyl-7-methyl-4-propionyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

• Synonyms: 1-Propionyl LSD, 1P-LSD

Physical Properties and Purity Standards

• Appearance: Solid pellets with 150 micrograms of 1P-LSD each, typically white to off-white crystalline material prior to pelletization.

• Purity: High-purity ≥ 98%, suitable for research and analytical purposes.

• Solubility: Soluble in organic solvents such as methanol, ethanol, and acetonitrile, with low aqueous solubility.

• Storage Recommendations: Store in dry, cool, dark conditions in airtight containers to preserve quality and stability, preferably refrigerated.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1P-LSD acts as a prodrug of LSD, being enzymatically converted to active LSD after administration. LSD then activates serotonin 5-HT2A receptors primarily responsible for psychedelic effects. This pathway allows 1P-LSD to produce classical psychedelic responses observed in rats and humans, albeit with a modified onset, duration, and potency due to the prodrug status.

Research Applications

Used in receptor binding studies, metabolic assays, and behavioral pharmacology to elucidate the influence of N1 substitution on structure-activity relationships. The pellet form supports precise microdose experiments in neuropharmacology and behavioral science research.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

1P-LSD has structural resemblance to LSD but features the propionyl moiety, differentiating it from 1B-LSD and 1cP-LSD by acyl chain length and metabolic profile. Its prodrug nature places it in a distinct pharmacokinetic category relative to direct LSD administration.

Advantages for Research

The 150 mcg pellet format facilitates consistent dosing, essential for clinical and preclinical research. 1P-LSD’s chemical stability and metabolic conversion provide distinct benefits in studying psychedelic drug metabolism and receptor dynamics.

Safety and Handling Guidelines

Laboratory Safety

Use gloves, lab coats, and eye protection. Handle pellets in ventilated spaces or fume hoods to avoid exposure. Avoid ingestion and inhalation.

Disposal and Environmental Considerations

Dispose as per hazardous chemical waste guidelines. Prevent contamination by careful waste management.

Regulatory Status

Regulated as a research chemical and controlled substance analog in several jurisdictions. Authorized for laboratory use only, not for human consumption.

Frequently Asked Questions (FAQs)

1. What dose is contained in 1P-LSD pellets?

• Each pellet contains 150 micrograms for precise research dosing.

2. How is 1P-LSD metabolized?

• Rapidly metabolizes to LSD in vivo, producing psychedelic effects.

3. How should the pellets be stored?

• In a cool, dry, dark, airtight environment; refrigeration recommended.

4. What solvents dissolve 1P-LSD?

• Methanol, ethanol, and acetonitrile are suitable solvents.

5. Is 1P-LSD legal?

• Regulatory restrictions apply; intended for regulated research use only.

Conclusion

1P-LSD 150 MCG Pellets offer a high-purity prodrug of LSD in a precise microdose pellet format. They are valuable tools for psychedelic research, enabling exploration of pharmacodynamics, receptor binding, and metabolic pathways under strict laboratory and regulatory controls.