IPPH (Isopropylphenidate) Product Description

Introduction

Isopropylphenidate (often abbreviated as IPPH) is a synthetic stimulant classified within the phenidate family, closely related structurally to methylphenidate (Ritalin). It features an isopropyl group in place of the methyl group of methylphenidate. IPPH acts primarily as a norepinephrine-dopamine reuptake inhibitor (NDRI), delivering stimulating effects related to enhanced dopamine and norepinephrine activity. It is used primarily as a research chemical to explore stimulant pharmacology and potential therapeutic applications.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C16H23NO2

• Molecular Weight: 261.36 g/mol

• CAS Number: 99088-49-0 (related isomers and analogs)

• IUPAC Name: Propan-2-yl 2-phenyl-2-(piperidin-2-yl)acetate

• Synonyms: Isopropylphenidate, IPH, IPPH, IPD, IPPD, Ritalinic acid isopropyl ester

Physical Properties

• Appearance: White to off-white crystalline powder

• Melting Point: ~227-228°C

• Solubility: Moderately soluble in organic solvents such as ethanol and DMSO; poorly soluble in water

• Stability: Stable under standard laboratory storage conditions

Pharmacological Profile and Mechanism of Action

• IPPH functions as a norepinephrine-dopamine reuptake inhibitor, blocking transporter proteins to increase extracellular dopamine and norepinephrine

• Produces stimulant, focus-enhancing, and mood-elevating effects similar to methylphenidate but with a potentially different potency and duration

• Less interaction with noradrenergic system compared to methylphenidate, possibly offering fewer cardiovascular effects

Research and Applications

• Research compound used to study psychostimulant pharmacodynamics and pharmacokinetics

• Used as a comparator in drug development for ADHD and other neuropsychiatric disorders

• Explored for its resistance to enzymatic hydrolysis, which may influence duration and efficacy

Safety and Handling

• Handle with standard laboratory PPE including gloves and eye protection

• Use in well-ventilated spaces, avoiding inhalation or skin contact

• Follow hazardous chemical disposal protocols

Regulatory Status

• Research chemical with restricted use to licensed laboratories

• Not approved for medical or human use

Frequently Asked Questions (FAQs)

1. What is Isopropylphenidate?
   A stimulant and norepinephrine-dopamine reuptake inhibitor related to methylphenidate.

2. What is its chemical formula?
   C16H23NO2.

3. How soluble is IPPH?
   Soluble in organic solvents; poorly soluble in water.

4. What is the CAS number?
   99088-49-0 (typical for key isomers).

5. What is its primary use?
   Research into psychostimulant mechanisms and drug development.

Conclusion

Isopropylphenidate (IPPH) is a valuable phenidate-class stimulant research chemical, known for its norepinephrine-dopamine reuptake inhibition properties and unique structural features influencing pharmacokinetics. Its use in research offers insight into stimulant pharmacology and potential therapeutic developments.