4-AcO-DET Fumarate Product Description

Introduction

4-AcO-DET fumarate is the fumaric acid salt form of 4-Acetoxy-N,N-diethyltryptamine (4-AcO-DET), a synthetic psychedelic tryptamine analog. This salt form enhances chemical stability, crystallinity, and handling convenience compared to the freebase or other salts. It is used primarily in scientific research to investigate serotonin receptor-mediated psychedelic effects, acting as a prodrug converting to 4-HO-DET in vivo.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: Off-white crystalline solid or powder.

• Purity: Typically ≥ 97%, verified by chromatographic and spectrometric methods.

• Solubility: Soluble in water, methanol, ethanol, and dimethyl sulfoxide (DMSO).

• Storage Recommendations: Store in airtight, light-resistant containers in cool, dry conditions, ideally refrigerated at -20°C for long-term stability.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4-AcO-DET fumarate functions as a serotonin 5-HT2A receptor agonist and prodrug to 4-HO-DET, mediating psychedelic effects including altered perception, mood enhancement, and hallucinations. Its acetoxy moiety undergoes enzymatic hydrolysis in vivo, releasing the active hydroxy compound. The fumarate salt provides better bioavailability and chemical stability.

Research Applications

Used in preclinical and clinical research focused on psychedelic pharmacodynamics, receptor binding, metabolism, and behavioral effects of tryptamine derivatives. Its chemical stability as a fumarate salt facilitates precise dosing and advanced analytical studies.

Safety and Handling Guidelines

Laboratory Safety

Employ personal protective equipment including gloves, lab coat, and eye protection. Conduct handling in well-ventilated areas or fume hoods.

Disposal and Environmental Considerations

Dispose of under hazardous waste regulations with measures to prevent environmental contamination.

Regulatory Status

4-AcO-DET fumarate is regulated as a research chemical in many jurisdictions and is restricted to licensed scientific use.

Frequently Asked Questions (FAQs)

1. How does 4-AcO-DET fumarate differ from freebase?

• Fumarate salt improves stability, solubility, and handling.

2. What is the active metabolite of 4-AcO-DET?

• 4-HO-DET, produced via enzymatic hydrolysis in the body.

3. What is the typical purity of 4-AcO-DET fumarate?

• Typically ≥ 97%.

4. How should 4-AcO-DET fumarate be stored?

• Refrigerated at -20°C in airtight, opaque containers.

5. Is 4-AcO-DET fumarate legal?

• It is controlled and authorized only for scientific research.

Conclusion

4-AcO-DET fumarate is a high-purity, stable salt form of the synthetic psychedelic 4-AcO-DET. It is used extensively in neuropharmacological research on psychedelic tryptamines, providing a reliable prodrug form with enhanced chemical and physical properties for precise scientific applications.