Deschloroetizolam 2mg Blotters

PRODUCT DESCRIPTION

Introduction

Deschloroetizolam 2mg blotters are a potent research chemical form of deschloroetizolam, a thienotriazolodiazepine closely related to etizolam and clonazolam. It is notable for producing depressant, anxiolytic, sedative, hypnotic, muscle-relaxant, anticonvulsant, and amnesic effects by modulating GABA receptors, similar to benzodiazepines. Deschloroetizolam has a relatively fast onset and prolonged duration compared to etizolam. At 2 mg per blotter, it is considered potent and suitable for detailed neuropharmacological and toxicological studies.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Name: 2-Ethyl-9-methyl-4-phenyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepine

• Chemical Formula: C17H16N4S

• Molecular Weight: 308.4 g/mol

• CAS Number: 40054-73-7

• Synonyms:

  • Deschloroetizolam

  • Thieno analogue of etizolam

2.2 Physical Properties and Purity Standards

• Appearance: Thin blotter papers impregnated with 2 mg of the active compound each

• Dosage Strength: 2 mg deschloroetizolam per blotter

• Purity: Pharmaceutical or research-grade purity, typically ≥98%

• Solubility: Soluble in dimethylformamide (5 mg/mL), DMSO (5 mg/mL), partial solubility in aqueous buffers

• Storage Recommendations: Store blotters in sealed containers, away from light, moisture, and at cool temperatures (ideally refrigerated) to maintain potency

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Deschloroetizolam binds allosterically at GABA-A receptors, enhancing GABAergic neurotransmission leading to central nervous system depressant effects. It shares effects similar to benzodiazepines but with unique potency and pharmacokinetics influenced by its thienotriazolodiazepine structure.

3.2 Research Applications

Used in receptor binding assays, neuropharmacology, behavioral studies, and toxicological research. The blotter administration allows for precise sublingual delivery and rapid absorption in pharmacokinetics studies.

Comparative Analysis with Related Compounds

4.1 Compared to Etizolam and Benzodiazepines

Deschloroetizolam is approximately half as potent as etizolam but with a longer duration of action, making it favorable for sustained CNS effects in research. Structurally distinct due to the absence of chlorine, it offers alternative receptor binding profiles valuable in experimental models.

4.2 Advantages for Research

Blotter formats provide easy handling, dose accuracy, and rapid absorption making them ideal for behavioral and pharmacokinetic studies.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle with gloves and eye protection in ventilated spaces to prevent accidental exposure and inhalation.

5.2 Disposal

Dispose of in accordance with hazardous waste regulations.

5.3 Regulatory Status

Varies significantly by jurisdiction. Monitor and comply with local controls concerning thienodiazepines.

Frequently Asked Questions (FAQs)

1. What is deschloroetizolam?
   A thienotriazolodiazepine research chemical with CNS depressant effects.

2. What is the dose per blotter?
   2 mg.

3. How is it administered?
   Typically sublingual via blotter paper.

4. What are its main effects?
   Anxiolytic, sedative, muscle relaxant, anticonvulsant.

5. Is it regulated?
   Yes, depending on the jurisdiction.

Conclusion

Deschloroetizolam 2 mg blotters provide a potent, pure, and stable research chemical form for detailed exploration of CNS depressant effects and GABA-A receptor pharmacology. Their delivery format enables precise dosing and bioavailability in sublingual administration studies under strict laboratory safety and regulatory compliance.