2F-DCK 100MG Pellets Product Description

Introduction

2F-DCK, also known as 2-Fluorodeschloroketamine, is a synthetic arylcyclohexylamine dissociative anesthetic and a structural analog of ketamine. It features a fluorine atom substitution at the ortho position of the phenyl ring, replacing the chlorine atom found in ketamine, while retaining the cyclohexanone core and methylated amine group. 2F-DCK pellets containing 100 mg of active compound provide a standardized format for scientific research focused on dissociative pharmacology, neuropharmacology, and forensic analysis. This product is intended solely for laboratory research.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White crystalline solid or pellets containing 100 mg of 2F-DCK each.

• Purity: Research-grade purity of ≥ 98% confirmed via chromatographic methods.

• Solubility: Soluble in polar organic solvents such as dimethylformamide (DMF) (~10 mg/mL), dimethyl sulfoxide (DMSO) (~5 mg/mL), ethanol (~5 mg/mL), methanol (~1 mg/mL), and aqueous phosphate-buffered saline (pH 7.2, 10 mg/mL).

• Storage Recommendations: Store in airtight, light-protected containers at cool temperatures (2-8°C) to maintain chemical stability; avoid moisture and prolonged exposure to ambient conditions.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

2F-DCK functions as a dissociative anesthetic through antagonism of the N-methyl-D-aspartate (NMDA) receptor subtype of glutamate receptors, similar to ketamine. It inhibits excitatory neurotransmission, producing dissociative, analgesic, and anesthetic effects. The fluorine substitution at the ortho position is thought to modulate its pharmacokinetics and receptor binding affinity, resulting in potentially longer duration and altered potency compared to ketamine.

Research Applications

2F-DCK is utilized extensively in neuropharmacological and toxicological studies to assess NMDA receptor antagonism, anesthetic efficacy, and comparative pharmacokinetics against ketamine and other analogs. It also serves as an analyte in forensic toxicology and drug screening due to its growing prevalence in recreational drug markets.

Comparative Analysis with Related Compounds

Comparison to Ketamine and Other Analogues

2F-DCK is structurally similar to ketamine but differs in its halogen substitution, replacing ketamine’s chlorine with fluorine. This substitution increases polar interactions and can affect metabolism and binding affinity. Compared with other deschloroketamine analogs, 2F-DCK has distinct pharmacokinetic profiles and receptor binding dynamics. Its metabolism is slower relative to ketamine, potentially resulting in extended effects.

Advantages for Research

• Provides a chemically well-defined compound for controlled NMDA receptor pharmacology studies.

• The fluorine substitution facilitates investigation into structure-activity relationships within arylcyclohexylamines.

• Useful in comparative behavioral and metabolic studies relevant to anesthetics and dissociative states.

Safety and Handling Guidelines

Laboratory Safety

Standard laboratory PPE including gloves, lab coat, and eye protection is required. Handle 2F-DCK in well-ventilated fume hoods to prevent inhalation and minimize direct skin contact.

Disposal and Environmental Considerations

Dispose of all waste per hazardous chemical regulations, using containment methods to prevent environmental exposure.

Regulatory Status

2F-DCK is regulated as a research chemical and a controlled substance in multiple countries. Use is restricted to licensed laboratories and scientific investigations.

Frequently Asked Questions (FAQs)

1. What is the mechanism of action of 2F-DCK?

• It primarily acts as an NMDA receptor antagonist producing dissociative effects.

2. How does 2F-DCK differ from ketamine?

• It has a fluorine substituent instead of chlorine, altering its pharmacokinetics and potency.

3. What is the typical dose in pellets?

• 100 mg of 2F-DCK per pellet.

4. How soluble is 2F-DCK?

• Soluble in DMF, DMSO, ethanol, methanol, and phosphate-buffered saline.

5. Is 2F-DCK controlled?

• Yes, it is regulated and intended only for scientific research.

Conclusion

2F-DCK 100 MG Pellets represent a high-purity, structurally unique dissociative research chemical closely related to ketamine. Its NMDA receptor antagonism, altered pharmacokinetics due to fluorine substitution, and high purity make it a significant compound for laboratory and neuropharmacological research under regulated conditions.