Flubrotizolam 0.5 MG Pellets Product Description

Introduction

Flubrotizolam 0.5 mg pellets are solid research dosage units containing 0.5 milligrams of pure Flubrotizolam, a highly potent thienotriazolodiazepine benzodiazepine analog. Known for its strong sedative, anxiolytic, muscle relaxant, and hypnotic effects, Flubrotizolam 0.5 mg pellets provide precise dosing for pharmacological and neuroscientific studies focused on GABA-A receptor modulation and CNS effects.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H12BrFN4S

• Molecular Weight: 377.24 g/mol

• CAS Number: 57801-95-3

• IUPAC Name: 2-bromo-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepine

• Synonyms: Flubrotizolam

2.2 Physical Properties and Pellet Specifications

• Appearance: White to off-white solid pellets

• Dosage: 0.5 mg Flubrotizolam per pellet

• Purity: ≥98% pharmaceutical or research grade

• Storage Recommendations: Store in airtight containers, cool, dry, and away from light to maintain potency and stability

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Flubrotizolam acts as a positive allosteric modulator of the GABA-A receptor, enhancing inhibition via benzodiazepine binding sites. This results in potent sedative, anxiolytic, muscle relaxant, and hypnotic effects. Its fluorine and bromine substitutions increase binding affinity and duration compared to traditional benzodiazepines.

3.2 Research Applications

Commonly used for studying benzodiazepine receptor pharmacology, CNS depression, anxiolytic mechanisms, and receptor binding dynamics. Pellets enable reliable dosing and consistent results in in vitro and in vivo studies.

Comparative Analysis with Related Compounds

4.1 Comparison with Alprazolam and Other Benzodiazepines

Flubrotizolam is more potent and longer-lasting due to chemical modifications, offering a powerful tool for precise CNS receptor studies compared to traditional benzodiazepines like alprazolam.

4.2 Advantages for Research

Pellets provide exact dosing, reducing variability over powders. The 0.5 mg dose suits various research models, from mild to strong benzodiazepine exposure studies.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle with gloves, lab coat, and eye protection. Use in well-ventilated spaces or fume hoods. Avoid inhalation and skin contact.

5.2 Disposal and Environmental Considerations

Dispose of as hazardous chemical waste according to regulations.

5.3 Regulatory Status

Flubrotizolam is regulated and intended solely for research. Strict adherence to legal requirements and institutional protocols is mandatory.

Frequently Asked Questions (FAQs)

1. What is the dosage per pellet?
   0.5 mg Flubrotizolam.

2. What are Flubrotizolam’s effects?
   Sedation, anxiolysis, muscle relaxation, hypnotic effects.

3. What solvents dissolve Flubrotizolam?
   DMSO, ethanol, methanol; low water solubility.

4. What research is Flubrotizolam used for?
   Benzodiazepine pharmacology and CNS receptor studies.

5. How should pellets be stored?
   Airtight container, cool, dry, light-protected.

Conclusion

Flubrotizolam 0.5 mg pellets provide reliable, high-potency benzodiazepine dosing for research on CNS depression and GABA receptor pharmacology. Their precise dosage and stability enable consistent, reproducible scientific investigations.