1P-LSD 10 MCG Pellets – Microdose Product Description

Introduction

1P-LSD, or 1-propionyl-lysergic acid diethylamide, is a semi-synthetic lysergamide and a chemically modified analog of LSD. It includes a propionyl group attached to the nitrogen-1 position of the lysergic acid molecule, altering its chemical and pharmacological profile. This compound is provided as 10 microgram pellets designed for precise microdosing in research environments. 1P-LSD serves primarily in scientific laboratories for investigating psychedelic effects and neuropharmacology without direct human consumption.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C23H29N3O2

• Molecular Weight: 379.5 g/mol

• CAS Number: 2349358-81-0

• IUPAC Name: (6aR,9R)-N,N-diethyl-7-methyl-4-propionyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

• Synonyms: 1-Propionyl LSD, 1P-Lysergic Acid Diethylamide, 1P-LSD

Physical Properties and Purity Standards

• Appearance: Small pellets formulated to contain 10 micrograms of 1P-LSD each. The compound in pure form is a crystalline powder that is colorless to white.

• Purity: Generally ≥ 98%, fitting the criteria for high-quality research chemicals.

• Solubility: Soluble in organic solvents including ethanol, methanol, and acetonitrile; limited solubility in water.

• Storage Recommendations: Store pellets in airtight, opaque containers, protected from light, moisture, and heat preferably at refrigerated temperatures to maintain potency.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1P-LSD functions as a full or partial agonist at serotonin 5-HT2A receptors, which are chiefly responsible for psychedelic effects. Scientific studies have demonstrated that 1P-LSD behaves as a prodrug, undergoing enzymatic hydrolysis in vivo to generate LSD, which then activates central serotonin receptors. Pharmacokinetic data from humans and animal models indicate rapid conversion of 1P-LSD to LSD, resulting in psychedelic effects consistent with traditional LSD, but with altered pharmacodynamics due to the prodrug nature.

Research Applications

This compound is extensively applied in neuropathological and pharmacological research to examine serotonergic receptor interactions, psychedelic mechanism elucidation, and metabolism. The microdose pellet format is ideal for dose-dependent studies emphasizing subtle neurological and behavioral effects in controlled environments.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

1P-LSD chemically varies from LSD by the addition of the propionyl group at nitrogen-1. This modification is similar in nature to other acylated analogs like 1B-LSD and 1cP-LSD but differs in chain length and pharmacokinetics. Compared with LSD, 1P-LSD has lower initial activity that is quickly converted into LSD in vivo, resulting in comparable long-term effects.

Advantages for Research

Pellets provide consistent and accurate dosing critical for research reproducibility. The prodrug nature of 1P-LSD allows study of pharmacokinetics, enzymatic metabolism, and receptor engagement distinct from immediate LSD effects. Its chemical stability and ease of handling make it suitable for diverse laboratory investigations.

Safety and Handling Guidelines

Laboratory Safety

Employ proper PPE such as gloves, lab coats, and eye protection. Handle pellets with care in well-ventilated or fume hood environments to avoid exposure. Prevent cross-contamination and accidental ingestion.

Disposal and Environmental Considerations

Follow established hazardous chemical waste disposal protocols to minimize environmental impact. Use chemical neutralization methods where appropriate.

Regulatory Status

1P-LSD is controlled under various research chemical legislations and regulated as a substance for scientific use only. It is not approved for human consumption and may be subject to restrictions depending on jurisdiction.

Frequently Asked Questions (FAQs)

1. What is 1P-LSD used for in research?

• Primarily for studying psychedelic receptor pharmacology and metabolism.

2. How rapidly does 1P-LSD convert to LSD?

• It is rapidly hydrolyzed to LSD within hours after ingestion.

3. How should 1P-LSD pellets be stored?

• In cool, dry, dark places, preferably refrigerated in airtight containers.

4. What solvents dissolve 1P-LSD?

• Soluble in methanol, ethanol, and acetonitrile.

5. Is 1P-LSD legal for research?

• Legal status varies but generally restricted to regulated laboratory research.

Conclusion

1P-LSD 10 MCG Pellets are precise-dose research chemicals offering a prodrug LSD analog with high purity and stability. Ideal for advanced neuropharmacological and behavioral studies, they support exploration of serotonergic psychedelics under stringent safety and regulatory standards.