1P-LSD 100 MCG Blotters Product Description

Introduction

1P-LSD, or 1-propionyl-lysergic acid diethylamide, is a semi-synthetic lysergamide and analog of LSD featuring a propionyl group attached at the nitrogen-1 position of the lysergic acid core. Supplied as blotters each impregnated with 100 micrograms of the compound, 1P-LSD is primarily used for precise scientific research and analytical studies exploring psychedelic neuropharmacology and structure-activity relationships. The compound serves as a prodrug to LSD, offering researchers an important tool for investigating psychedelic receptor interactions and metabolism.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C23H29N3O2

• Molecular Weight: Approximately 379.5 g/mol

• CAS Number: 2349358-81-0

• IUPAC Name: (6aR,9R)-N,N-diethyl-7-methyl-4-propionyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

• Synonyms: 1-Propionyl LSD, 1P-LSD, 1P-lysergic acid diethylamide

Physical Properties and Purity Standards

• Appearance: Thin paper blotters containing 100 micrograms of 1P-LSD each. The raw compound is a colorless to white crystalline powder.

• Purity: Generally ≥ 98%, consistent with research-grade standards verified by analytical techniques such as NMR and HPLC.

• Solubility: Soluble in organic solvents including methanol, ethanol, and acetonitrile; limited solubility in water.

• Storage Recommendations: Store blotters in airtight, light-resistant containers, in cool and dry conditions, preferably refrigerated to maintain chemical stability and potency over time.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1P-LSD is a potent agonist at serotonin 5-HT2A receptors, the primary receptor subtype responsible for the psychedelic effects of LSD and related compounds. Upon administration, 1P-LSD is enzymatically hydrolyzed in vivo to release LSD, which then binds to central serotonin receptors, eliciting classic psychedelic effects. This prodrug mechanism modifies onset times and potency compared to direct LSD administration but ultimately leads to similar neuropharmacological outcomes.

Research Applications

1P-LSD is widely used in pharmacological research to study serotonergic psychedelic receptor systems, ligand binding affinities, and metabolism. The blotter format allows precisely controlled dosing for microdosing studies, behavioral experiments, and biochemical assays, providing reliable reproducibility essential for research integrity.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Chemically related to LSD, 1P-LSD differs in having the propionyl group which affects its pharmacokinetics and metabolic activation. It shares similarities with other N1-acylated LSD derivatives such as 1B-LSD and 1cP-LSD but varies in duration, potency, and metabolic rate. The prodrug nature of 1P-LSD results in delayed but prolonged systemic LSD exposure.

Advantages for Research

The pellet format ensures consistent and reproducible dosing for research applications focused on microdose effects and neuropharmacology. 1P-LSD’s distinct metabolic profile enables investigation of enzymatic cleavage, receptor activation dynamics, and structure-activity mechanisms in psychedelics.

Safety and Handling Guidelines

Laboratory Safety

Handle using appropriate PPE, including gloves, lab coat, and eye protection. Avoid aerosolization or direct contact with powders and solutions. Use well-ventilated areas or fume hoods for manipulation.

Disposal and Environmental Considerations

Dispose of substances and contaminated materials as hazardous chemical waste per institutional and legal regulations. Prevent environmental contamination through careful containment and neutralization.

Regulatory Status

1P-LSD is regulated as a research chemical and controlled substance in many countries. It is intended solely for scientific research and not for human consumption.

Frequently Asked Questions (FAQs)

1. What is 1P-LSD primarily used for?

• Research on serotonergic psychedelics and microdose neuropharmacology.

2. How quickly does 1P-LSD convert to LSD?

• Rapid enzymatic hydrolysis converts it to LSD typically within hours.

3. How should 1P-LSD blotters be stored?

• In cool, dry, dark, and airtight conditions, ideally refrigerated.

4. What solvents dissolve 1P-LSD?

• Methanol, ethanol, and acetonitrile dissolve 1P-LSD well.

5. Is 1P-LSD legal to use?

• It is restricted and permitted only for licensed research use in most regions.

Conclusion

1P-LSD 100 MCG Blotters provide a high-purity prodrug of LSD, enabling controlled neuropharmacological research through precise dosing. Their stability, purity, and prodrug behavior facilitate comprehensive studies on psychedelic receptor interactions and metabolism under regulatory compliance.