4-HO-DET Fumarate Product Description

Introduction

4-Hydroxy-N,N-diethyltryptamine (4-HO-DET) fumarate is the fumaric acid salt form of 4-HO-DET, a synthetic psychedelic tryptamine related to psilocin. The fumarate salt improves the compound’s chemical stability and crystallinity, which is essential for precise dosing and handling in research settings. 4-HO-DET is known to act as a serotonin receptor agonist, producing classic psychedelic effects such as altered visual and sensory perception, mood enhancement, and intensified introspection.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: Off-white crystalline or powder solid.

• Purity: Typically ≥ 97%, validated by spectrometric and chromatographic analysis.

• Solubility: Soluble in polar solvents including methanol, ethanol, DMSO, and water (due to salt form).

• Storage Recommendations: Store in airtight, light-shielded containers under cool, dry conditions, preferably refrigerated at -20°C.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4-HO-DET fumarate acts as a selective agonist at serotonin 5-HT2A receptors, responsible for its psychedelic effects. The compound’s indole structure and hydroxy substitution enable binding to these receptors, modulating brain signaling pathways involved in perception and cognition.

Research Applications

Widely utilized in neuropharmacological research to investigate serotonin receptor activity, psychedelic mechanisms of action, and behavioral effects. The fumarate salt ensures reproducibility and improved chemical handling, supporting biomedical and forensic studies.

Safety and Handling Guidelines

Laboratory Safety

User protection requires gloves, lab coat, and eye protection. Handling should be done in well-ventilated spaces or fume hoods.

Disposal and Environmental Considerations

Dispose of chemical residues following hazardous waste regulations.

Regulatory Status

4-HO-DET fumarate is regulated and restricted for use in licensed scientific research.

Frequently Asked Questions (FAQs)

1. What is 4-HO-DET fumarate?

• It is the fumaric acid salt of 4-Hydroxy-N,N-diethyltryptamine, a psychedelic tryptamine.

2. What receptors does it affect?

• Primarily serotonin 5-HT2A receptors.

3. What purity is typical?

• Research-grade purity ≥ 97%.

4. How should it be stored?

• Refrigerated at -20°C in airtight, light-protected containers.

5. Is 4-HO-DET fumarate legal?

• Controlled, permitted only for authorized research use.

Conclusion

4-HO-DET fumarate is a stable, high-purity psychedelic tryptamine salt used extensively for controlled neuropharmacological research. Its serotonin receptor agonism and enhanced chemical stability make it a valuable tool in studying psychedelic mechanisms.