4F-MPH (4-Fluoromethylphenidate) Product Description

Introduction

4F-MPH, or 4-Fluoromethylphenidate, is a synthetic stimulant drug related to methylphenidate, widely known for its dopamine reuptake inhibitory effects. It acts as a more potent dopamine reuptake inhibitor compared to methylphenidate. This compound is part of the phenidate family and is used primarily in neuropharmacological research due to its stimulant properties and structural novelty.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White crystalline solid, often available as hydrochloride salt (±)-threo- and (±)-erythro- diastereomers.

• Boiling Point: Approximately 329.4±22.0 °C (predicted).

• Density: 1.130±0.06 g/cm3 (predicted).

• pKa: 9.49±0.10 (predicted).

• Purity: Research-grade purity ≥ 98%, often supplied in racemic mixtures.

• Solubility: Soluble in solvents such as DMSO, ethanol, and methanol.

• Storage: Recommended storage is airtight containers, protected from light, at -20°C.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4F-MPH acts primarily as a dopamine reuptake inhibitor, enhancing dopaminergic neurotransmission in the brain, which improves focus, alertness, and energy. The addition of the fluorine atom increases potency and modifies metabolic stability relative to methylphenidate.

Research Applications

4F-MPH is utilized in neuroscience and pharmacological research to investigate stimulant mechanisms, dopamine transporter interactions, and potential therapeutic applications.

Safety and Handling Guidelines

Laboratory Safety

Standard laboratory personal protective equipment such as gloves, lab coat, and goggles should be used. Handle in well-ventilated areas or fume hoods.

Disposal and Environmental Considerations

Dispose of chemical waste according to hazardous substances regulations.

Regulatory Status

4F-MPH is regulated in some jurisdictions; use is limited to authorized research settings.

Frequently Asked Questions (FAQs)

1. What is 4F-MPH chemically?

• A fluorinated analogue of methylphenidate acting as a potent dopamine reuptake inhibitor.

2. What is its molecular weight and formula?

• Molecular weight 251.30 g/mol; formula C14H18FNO2.

3. What purity is typical?

• Research-grade ≥ 98%.

4. How is 4F-MPH soluble?

• Soluble in DMSO, ethanol, methanol.

5. How should it be stored?

• Airtight, protected from light, frozen or refrigerated at -20°C.

6. Is 4F-MPH legal?

• Controlled or regulated, restricted to research use.

Conclusion

4F-MPH is a high-purity fluorinated stimulant with significance in dopaminergic research. Its increased potency compared to methylphenidate makes it a critical compound for stimulant pharmacology and toxicology studies.