Ativan 1MG

PRODUCT DESCRIPTION

Introduction

Ativan is the brand name for lorazepam, a short-acting benzodiazepine medication primarily used to manage anxiety disorders, insomnia, and status epilepticus. Ativan 1mg tablets offer a precise dose of lorazepam for research and clinical simulation purposes. Lorazepam is a sedative, anxiolytic, anticonvulsant, and muscle relaxant, widely prescribed in medical settings. It appears as a white to off-white solid tablet formulated for oral administration, facilitating fast absorption and rapid onset of action.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H10Cl2N2O2

• Molecular Weight: 321.2 g/mol

• CAS Number: 846-49-1

• IUPAC Name: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one

• Synonyms:

  • Lorazepam

  • Ativan (brand)

  • Tavor

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white solid tablets, round or oval-shaped

• Purity: Pharmaceutical grade ≥99% purity typical

• Solubility: Practically insoluble in water, soluble in ethanol and organic solvents

• Storage Recommendations: Store at controlled room temperature (20-25°C), protected from moisture, light, and heat

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Lorazepam enhances the effect of the neurotransmitter gamma-aminobutyric acid (GABA) by binding to GABA-A receptor sites. It increases the frequency of chloride channel opening, resulting in neuronal hyperpolarization, reduced excitability, and anxiolytic, sedative-hypnotic, muscle-relaxant, and anticonvulsant effects.

3.2 Research Applications

Ativan 1mg tablets are used in pharmacological research for studying benzodiazepine receptor pharmacodynamics, anxiolytic mechanisms, and sedative effects. It is employed in behavioral and neurochemical experiments, as well as in pharmacokinetic profiling and drug interaction studies.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

Lorazepam is closely related to other benzodiazepines such as diazepam and clonazepam but has a shorter half-life and faster onset. Compared to alprazolam, lorazepam exhibits stronger sedative properties with less pronounced euphoric effects.

4.2 Advantages for Research

The 1mg tablet dosage enables accurate dosing and dose-ranging studies. Lorazepam’s well-characterized receptor binding profile facilitates reproducible experimental results and mechanistic insights into anxiolytic and anticonvulsant pharmacology.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle with gloves, protective eyewear, and lab coagulation. Use in a well-ventilated environment. Avoid inhalation or ingestion outside controlled dosing.

5.2 Disposal and Environmental Considerations

Dispose of unused or expired tablets in compliance with medical waste regulations to prevent environmental contamination.

5.3 Regulatory Status

Lorazepam is a Schedule IV controlled substance in the US and similarly regulated internationally. Usage and possession are restricted to licensed medical and research facilities.

Frequently Asked Questions (FAQs)

1. What is the typical dosage of Ativan?
   1 mg is a common dose for anxiety and sedation, adjustable per clinical context.

2. What receptors does lorazepam act on?
   GABA-A receptor modulatory sites.

3. What are the clinical uses of Ativan?
   Anxiety relief, sedation, seizure control, and muscle relaxation.

4. Is Ativan water soluble?
   It has very low water solubility, soluble in ethanol.

5. Is lorazepam legally controlled?
   Yes, it is Schedule IV under DEA and similarly regulated worldwide.

Conclusion

Ativan 1mg tablets provide a precise, high-purity formulation of lorazepam, a benzodiazepine with well-established anxiolytic and sedative pharmacology. Their consistency and stability make them valuable for pharmacological research with critical emphasis on safety and compliance with regulatory frameworks.