Bromantane

PRODUCT DESCRIPTION

Introduction

Bromantane is a synthetic adamantane derivative known for its stimulant, anxiolytic, and adaptogenic properties. It was originally developed in Russia and is used for its ability to enhance physical endurance, cognitive function, and reduce fatigue under stress without increasing oxygen consumption. Bromantane is researched extensively for its neuroprotective, neurochemical, and psychostimulant effects.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C16H20BrN

• Molecular Weight: 306.24 g/mol

• CAS Number: 87913-26-6

• IUPAC Name: N-(4-bromophenyl)adamantan-2-amine

• Synonyms:

  • Bromantan

  • Ladasten

  • N-(4-Bromophenyl)-2-adamantanamine

  • 2-(4-Bromophenyl)aminoadamantane

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Purity: ≥98% purity for research-grade batches

• Solubility: Poorly soluble in water; soluble in ethanol, dimethyl sulfoxide (DMSO), acetone, and other organic solvents

• Melting Point: Approximately 146–149°C

• Storage Recommendations: Store in a cool, dry place at controlled room temperature or refrigerated for long-term stability, protected from light and moisture

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Bromantane enhances dopaminergic functioning by increasing dopamine synthesis through enzyme upregulation. It also potentiates GABAergic neurotransmission by strengthening GABA-mediated signaling and may exert serotonergic effects. These mechanisms contribute to its stimulant and anxiolytic actions without the classical side effects of amphetamines.

3.2 Research Applications

Used as a neuroprotective agent in research, bromantane is studied for its role in improving physical and mental stamina, cognitive enhancement, and adaptogenic properties. It is also investigated for potential therapeutic benefits in neurological disorders and conditions involving fatigue and stress.

Comparative Analysis with Related Compounds

4.1 Compare the compound to Compound(s) often compared to

Bromantane shares structural similarities with adamantane derivatives like amantadine and memantine but differs pharmacologically with enhanced dopaminergic stimulation and anxiolytic effects. Compared to amphetamines, it produces stimulant effects without the pronounced cardiovascular strain or addiction potential.

4.2 Advantages for Research

Bromantane’s stimulant yet anxiolytic profile makes it unique for research into balanced cognitive and physical performance enhancement. Its chemical stability and high purity support reproducible pharmacological and biochemical studies.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use gloves, lab coats, and eye protection when handling. Work in well-ventilated areas or fume hoods to avoid dust inhalation.

5.2 Disposal and Environmental Considerations

Dispose according to chemical hazardous waste regulations. Avoid environmental contamination.

5.3 Regulatory Status

Bromantane is regulated in some regions; researchers should verify local regulations before procurement or use.

Frequently Asked Questions (FAQs)

1. What is bromantane used for in research?
   To study neuroprotection, cognitive enhancement, and physical performance under stress.

2. How does bromantane differ from other stimulants?
   It boosts dopamine synthesis with less cardiovascular stimulation and addiction risk.

3. What is the typical purity of research-grade bromantane?
   Generally ≥98%.

4. Is bromantane water soluble?
   Poorly soluble in water, better in organic solvents.

5. What is bromantane’s melting point?
   Approximately 146 to 149 °C.

Conclusion

Bromantane is a high-purity, neurostimulating adamantane derivative used in research to investigate cognitive enhancement and adaptogenic effects. Its distinct pharmacology offers advantage over classical stimulants, making it a valuable research chemical under proper handling and regulatory compliance.