Clonazolam Pellets 1mg

PRODUCT DESCRIPTION

Introduction

Clonazolam pellets 1mg are a potent research chemical form of clonazolam, a triazolobenzodiazepine that is structurally related to clonazepam and alprazolam. Clonazolam exhibits strong anxiolytic, sedative, muscle relaxant, and hypnotic properties, making it an important compound for neuroscience and pharmacological research. These pellets provide precise 1 mg doses, suitable for in vitro and in vivo studies requiring controlled benzodiazepine receptor modulation.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H12ClN5O2

• Molecular Weight: 353.76 g/mol

• CAS Number: 33887-02-4

• IUPAC Name: 6-(2-Chlorophenyl)-1-methyl-8-nitro-4H-triazolo[4,3-a]benzodiazepine

• Synonyms:

  • Clonazolam

  • Clonitrazolam (alternative name)

  • 1-Methyl-6-(2-chlorophenyl)-8-nitro-4H-s-triazolo[4,3-a]benzodiazepine

2.2 Physical Properties and Purity Standards

• Appearance: White crystalline pellets

• Dosage Strength: 1 mg per pellet

• Purity: Pharmaceutical-grade, typically ≥98% pure

• Solubility: Approximately 0.0426 mg/mL soluble in water; soluble in organic solvents such as ethanol, DMSO

• Melting Point: Not reliably reported

• Storage Recommendations: Store in a cool, dry place away from light and heat; refrigeration at 4°C recommended for long-term storage

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Clonazolam is a potent positive allosteric modulator of GABA-A receptors, enhancing GABAergic inhibitory neurotransmission. It produces rapid sedative, anxiolytic, muscle-relaxant, and anticonvulsant effects with a medium onset time (20–60 minutes) and a half-life of approximately 3.6 hours.

3.2 Research Applications

Primarily utilized for research on benzodiazepine pharmacodynamics, receptor binding, metabolism, toxicology, and behavioral impact. The pellet form allows convenient, accurate dosing in experimental models and forensic studies.

Comparative Analysis with Related Compounds

4.1 Compared to Clonazepam and Alprazolam

Clonazolam surpasses clonazepam and alprazolam in potency on a per mg basis and exhibits a novel triazolo substitution impacting receptor binding affinity and pharmacokinetics. Its potency necessitates careful handling and dosing in research to avoid overdose.

4.2 Advantages for Research

The pellet dosage form offers stability, precise dosing, and ease of handling compared to powders or liquids. It facilitates reliable research results in benzodiazepine receptor studies.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use gloves, masks, and eye protection. Handle in well-ventilated areas or fume hoods to prevent inhalation or skin exposure.

5.2 Disposal and Environmental Considerations

Dispose according to controlled substance hazardous waste regulations.

5.3 Regulatory Status

Clonazolam is regulated or controlled in various countries, with scheduling based on potential for abuse and harm. Confirm legal status before use.

Frequently Asked Questions (FAQs)

1. What is clonazolam?
   A potent triazolobenzodiazepine benzodiazepine receptor modulator.

2. What is the dosage per pellet?
   1 mg.

3. What are common effects?
   Strong sedative, anxiolytic, and muscle-relaxant effects.

4. Is clonazolam water soluble?
   Poorly soluble in water; better in organic solvents.

5. Is it regulated?
   Yes, regulated in many regions globally.

Conclusion

Clonazolam 1 mg pellets provide a high-purity, potent benzodiazepine research chemical suitable for detailed pharmacological and toxicological studies. Their stable pellet form ensures accurate dosing and improved experimental reproducibility in controlled laboratory environments.