DOC Blotters Product Description

Introduction

DOC blotters are small pieces of absorbent paper infused with DOC (4-chloro-2,5-dimethoxyamphetamine), a synthetic psychedelic drug from the phenethylamine and amphetamine families. These blotters resemble LSD tabs in form and usage but contain DOC as the active compound. DOC is typically presented in white or off-white crystalline form prior to blotting and is known for its potent psychoactive effects mediated through serotonin receptor activity. DOC blotters are primarily used in controlled research environments for studying hallucinogenic pharmacology and receptor binding, not for human consumption.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C11H16ClNO2

• Molecular Weight: Approximately 221.7 g/mol

• CAS Number: 39063-76-4

• IUPAC Name: 1-(4-chloro-2,5-dimethoxyphenyl)propan-2-amine

• Synonyms: 4-Chloro-2,5-dimethoxyamphetamine, DOC, STP

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder prior to blotting

• Purity: Typically ≥97% in research-grade compounds

• Solubility: Soluble in water, alcohol, and organic solvents used in blotting paper preparation

• Storage Recommendations: Store blotters in a cool, dry place away from sunlight and moisture to preserve potency and stability

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

DOC acts primarily as a partial agonist at serotonin 5-HT2A and 5-HT2C receptors. This receptor binding underlies its psychedelic effects by altering neural signaling pathways involved in perception, cognition, and mood. Its activity produces potent hallucinogenic and sensory-altering effects in animal models, correlating with receptor affinities in the low nanomolar range.

3.2 Research Applications

Researchers utilize DOC blotters to examine serotonin receptor pharmacodynamics, hallucinogen receptor interactions, and the neurochemical basis of psychedelic effects. The blotter form facilitates precise dosing and handling in experimental setups, including behavioral pharmacology and receptor binding assays. DOC serves as an important model compound in psychopharmacology studies.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

DOC is chemically related to other DOx series compounds like DOB and DOM and shares structural similarity with 2C-class psychedelics. Compared to LSD blotters, DOC blotters have longer onset times (1–3 hours) and duration (up to 20 hours), with distinct psychoactive profiles focusing on visual and sensory effects. DOC’s effect profile includes both stimulant and hallucinogenic properties, differentiating it from classical psychedelics.

4.2 Advantages for Research

DOC blotters enable reproducible, calibrated dosing in experimental research, crucial for accurate pharmacological assessments. Their similarity to LSD blotters allows comparative studies in hallucinogen pharmacology. The compound’s strong receptor affinity and well-characterized effects provide a reliable framework for serotonin receptor-focused research.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle DOC blotters with gloves to avoid skin contact. Use in a controlled lab environment with ventilation. Avoid inhalation or ingestion. Handle according to hazardous chemical protocols due to potent bioactivity.

5.2 Disposal and Environmental Considerations

Dispose of DOC blotters as hazardous chemical waste in accordance with institutional and governmental regulations. Prevent environmental release.

5.3 Regulatory Status

DOC is controlled or regulated in many jurisdictions, often classified as a Schedule I or equivalent substance. Its possession, distribution, or use outside research settings is illegal in many countries. Compliance with all applicable legal requirements is mandatory.

Frequently Asked Questions (FAQs)

1. What is the chemical structure of DOC?
   1-(4-chloro-2,5-dimethoxyphenyl)propan-2-amine.

2. What receptors does DOC primarily target?
   Serotonin 5-HT2A and 5-HT2C receptors.

3. How does DOC blotters’ duration compare to LSD?
   DOC blotters have a longer duration, up to 20 hours compared to LSD’s 8–12 hours.

4. What is the common purity level of DOC used in blotters?
   Typically ≥97% research-grade.

5. Are DOC blotters legal for human consumption?
   No, DOC blotters are for research only and are legally restricted in many regions.

Conclusion

DOC blotters provide a stable, precise delivery method of the potent psychedelic compound DOC for research purposes. They facilitate the study of serotonin receptor-mediated hallucinogenic effects and hold significant value in neuropharmacology and psychopharmacology research due to their consistent dosing and well-characterized receptor pharmacology.