F-Phenibut (4-Fluorophenibut) Product Description

Introduction

F-Phenibut, scientifically known as β-(4-Fluorophenyl)-GABA, is a fluorinated analog of Phenibut, a GABAergic compound known for its anxiolytic and nootropic properties. This compound possesses a fluorine atom substitution at the para position of the phenyl ring, which alters its pharmacological profile compared to Phenibut. F-Phenibut is commonly found as a white to off-white crystalline powder suitable for research applications involving GABA-B receptor modulation and neurological studies.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C10H12FNO2

• Molecular Weight: 233.67 g/mol

• CAS Number: 1858241-03-8

• IUPAC Name: 4-fluoro-phenyl-gamma-aminobutyric acid

• Synonyms: 4-Fluorophenibut, F-Phenibut, β-(4-Fluorophenyl)-GABA

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline solid

• Purity: Typically ≥98% for research-grade quality

• Solubility: May dissolve in DMSO, ethanol, methanol, and variably in water; solubility depends on formulation

• Storage Recommendations: Stable at room temperature for short periods; best stored in a cool, dry place; avoid repeated freeze-thaw cycles when in solution

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

F-Phenibut acts as a potent agonist at GABA-B receptors, enhancing inhibitory neurotransmission through opening of potassium channels and suppression of neuronal excitability. Its fluorine substitution leads to higher affinity and potency at the receptor compared to Phenibut, influencing calming, anxiolytic, and muscle relaxant effects in research models.

3.2 Research Applications

F-Phenibut is used in neuropharmacological research exploring GABAergic pathways, receptor binding dynamics, and therapeutic potential in neurological and psychiatric disorders. Studies investigate its effects on synaptic transmission, neuronal excitability, and possible nootropic applications.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

Compared to Phenibut, F-Phenibut shows increased affinity and potency at GABA-B receptors due to the electronegative fluorine atom, which affects binding and metabolism. It is structurally similar to baclofen and tolibut but differs in receptor affinity profile. The fluorination enhances lipophilicity and possibly improves blood-brain barrier penetration.

4.2 Advantages for Research

F-Phenibut’s enhanced receptor potency enables lower dosage use in research, reducing off-target effects. The modification offers insights into structure-activity relationships within the GABAergic system. Its chemical stability and high purity facilitate reproducible experimental design.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle with standard laboratory PPE including gloves, lab coat, and eye protection. Work in ventilated areas to avoid inhalation. Avoid direct skin contact.

5.2 Disposal and Environmental Considerations

Dispose of chemical waste in compliance with institutional protocols. Prevent environmental contamination.

5.3 Regulatory Status

F-Phenibut is a research chemical not approved for clinical use. It is regulated in some jurisdictions. Usage must comply with relevant legal and institutional regulations.

Frequently Asked Questions (FAQs)

1. What is the molecular weight of F-Phenibut?
   233.67 g/mol.

2. What is the key pharmacological target of F-Phenibut?
   The GABA-B receptor.

3. How does F-Phenibut differ from Phenibut?
   It has a fluorine substitution increasing receptor affinity and potency.

4. What solvents are suitable for dissolving F-Phenibut?
   DMSO, ethanol, methanol; partial solubility in water.

5. What are common research applications?
   Neuropharmacology, GABAergic pathway studies, receptor binding experiments.

Conclusion

F-Phenibut (4-Fluorophenibut) is a potent fluorinated GABA-B receptor agonist used in research to explore inhibitory neurotransmission, anxiolytic mechanisms, and neuropharmacology. Its highly specific binding profile and enhanced potency make it valuable for detailed receptor studies.