Flubromazepam Pure Product Description

Introduction

Flubromazepam is a potent benzodiazepine derivative belonging to the triazolobenzodiazepine class. It is structurally related to phenazepam but differs due to the substitution of a fluorine atom on the phenyl ring, enhancing its potency and receptor affinity. As a pure compound, Flubromazepam appears as a white to off-white crystalline powder and is primarily used in pharmacological and neuropharmacological research exploring benzodiazepine receptor interactions, sedation, anxiolysis, and muscle relaxation.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H10BrFN2O

• Molecular Weight: 333.16 g/mol

• CAS Number: 2647-50-9

• IUPAC Name: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

• Synonyms: Flubromazepam, bromoflubromazepam, fluorophenazepam

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Purity: Typically ≥99% research/pharmaceutical grade

• Solubility: Soluble in dimethylformamide (DMF), dimethyl sulfoxide (DMSO) at 25 mg/mL, ethanol (~10 mg/mL), methanol (~1 mg/mL), and partially soluble in 1:1 DMSO to phosphate-buffered saline (~0.5 mg/mL)

• Melting Point: 189–190°C

• Storage Recommendations: Store in airtight containers in a cool, dry, and light-protected environment

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Flubromazepam acts as a positive allosteric modulator of GABA-A receptors at the benzodiazepine binding site. This enhances GABAergic inhibition, resulting in potent sedative, anxiolytic, muscle relaxant, and hypnotic effects. Its fluorine substitution contributes to a longer duration of action and higher potency compared to many traditional benzodiazepines.

3.2 Research Applications

Used extensively in neuropharmacology research to study benzodiazepine receptor pharmacodynamics, CNS inhibitory mechanisms, receptor binding studies, and metabolic pathways. It serves as a model compound for potent benzodiazepines in behavioral and toxicology research.

Comparative Analysis with Related Compounds

4.1 Comparison with Phenazepam and Other Benzodiazepines

Flubromazepam is more potent than phenazepam due to the additional fluorine atom. It exhibits longer pharmacological effects than alprazolam and diazepam, providing a valuable research tool for studying high potency benzodiazepine effects.

4.2 Advantages for Research

Its high purity and crystalline form allow for precise, consistent dosing and reliable experimental results. The compound’s profile supports detailed investigations into CNS function and benzodiazepine structure-activity relationships.

Safety and Handling Guidelines

5.1 Laboratory Safety

Wear gloves, lab coat, and eye protection when handling. Use in well-ventilated areas or fume hoods. Avoid inhalation and direct skin contact.

5.2 Disposal and Environmental Considerations

Dispose of waste according to hazardous chemical protocols to prevent environmental contamination.

5.3 Regulatory Status

Flubromazepam is controlled in multiple jurisdictions and is restricted to research use only. Compliance with local laws and regulatory standards is mandatory.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of Flubromazepam?
   C15H10BrFN2O.

2. What is the melting point?
   Approximately 189–190°C.

3. What solvents dissolve Flubromazepam?
   DMF, DMSO, ethanol, methanol; partial solubility in aqueous buffers.

4. What is its main mechanism?
   Positive allosteric modulation of GABA-A benzodiazepine receptors.

5. How is it stored?
   Airtight container in cool, dry, dark place.

Conclusion

Pure Flubromazepam is a high-potency benzodiazepine research chemical with excellent receptor affinity and prolonged pharmacological effects. Its physical stability and high purity enable robust CNS pharmacological research.