Fluclotizolam 0.5mg Pellets Product Description

Introduction

Fluclotizolam is a thienotriazolodiazepine benzodiazepine analog known for its potent sedative, anxiolytic, and muscle relaxant effects. The 0.5 mg pellets provide a precise, solid dosage form, ideal for research to study GABA-A receptor modulation and CNS depressant activity. Fluclotizolam combines benzodiazepine pharmacology with unique structural features, including fluorination and thieno ring systems, contributing to its potency and duration.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H10ClFN4S

• Molecular Weight: 332.78 g/mol

• CAS Number: 54123-15-8

• IUPAC Name: 2-chloro-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepine

• Synonyms: Fluclotizolam

2.2 Physical Properties and Pellet Specifications

• Appearance: White to off-white pellets

• Dosage: 0.5 mg per pellet

• Purity: ≥99% pharmaceutical/research grade

• Solubility: Soluble in DMSO, DMF (~5 mg/mL), partially soluble in phosphate-buffered saline (~0.5 mg/mL), ethanol (~10 mg/mL)

• Storage Recommendations: Store in airtight containers, cool, dry, and shielded from light in order to preserve chemical integrity

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Fluclotizolam acts as a high-affinity positive allosteric modulator of the GABA-A receptor, enhancing the inhibitory effects of GABA neurotransmission leading to CNS depression including sedation, anxiolysis, and muscle relaxation. Its fluorine and chloro substitutions provide increased receptor binding affinity and longer duration relative to classical benzodiazepines.

3.2 Research Applications

It is utilized in neuropharmacological studies focusing on benzodiazepine receptor binding, behavioral sedative effects, and pharmacokinetic profiling. The pellet form allows for precise and reproducible dosing in both in vitro and in vivo experimental models.

Comparative Analysis with Related Compounds

4.1 Comparison with Other Benzodiazepines

Fluclotizolam exhibits more potent and prolonged effects than many traditional benzodiazepines due to its unique thienotriazolodiazepine core and halogen substitutions. It is closely related to compounds such as flualprazolam but differs in specific halogen placement and receptor kinetics.

4.2 Advantages for Research

Pellets provide accurate dosing which mitigates variability in research outcomes. Its high purity and chemical stability support rigorous neurochemical and behavioral investigations.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle with gloves, lab coat, and protective eyewear. Use in well-ventilated spaces or fume hoods; avoid inhalation and direct skin exposure.

5.2 Disposal and Environmental Considerations

Dispose of via hazardous chemical waste channels according to institutional and environmental guidelines.

5.3 Regulatory Status

Fluclotizolam is a research-only chemical and is regulated in various jurisdictions. Legal compliance is mandatory.

Frequently Asked Questions (FAQs)

1. What is the molecular formula?
   C15H10ClFN4S.

2. What dosage per pellet?
   0.5 mg per pellet.

3. What solvents dissolve Fluclotizolam?
   DMSO, DMF, ethanol, partially in aqueous buffers.

4. What receptor does Fluclotizolam target?
   GABA-A receptor benzodiazepine binding site.

5. What are typical research uses?
   Benzodiazepine receptor studies, CNS depressant evaluation.

Conclusion

Fluclotizolam 0.5 mg pellets offer a potent and precise dosage form of a fluorinated benzodiazepine analog for neuroscience and pharmacology research. Their chemical stability, potency, and reliable dosing make them ideal for controlled receptor binding and CNS pharmacodynamic studies.