Norflurazepam Product Description

Introduction

Norflurazepam, also known as N-Desalkylflurazepam or 2-oxoquazepam, is a pharmacologically active benzodiazepine metabolite of drugs such as flurazepam, quazepam, and fludiazepam. It exhibits anxiolytic, sedative, muscle relaxant, and anticonvulsant properties. Norflurazepam has a long elimination half-life and contributes significantly to the prolonged effects of its parent compounds.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C15H10ClFN2O

• Molecular Weight: 288.7 g/mol

• CAS Number: 2886-65-9

• IUPAC Name: 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

• Synonyms: Norflurazepam, N-desalkylflurazepam, 2-oxoquazepam

Physical Properties and Purity

• Appearance: White to off-white crystalline powder

• Stability: Stable under proper storage conditions

• Storage: Store in a cool, dry, dark place

Pharmacological Profile and Mechanism of Action

• Acts as a positive allosteric modulator at GABA-A receptors

• Produces CNS depressant effects including anxiolysis, sedation, muscle relaxation, and anticonvulsant activity

• Long half-life contributes to prolonged duration of action and accumulation with repeated dosing

Research Applications

• Pharmacokinetics and metabolism studies of benzodiazepines

• Analytical studies and forensic toxicology

• Investigations on benzodiazepine receptor pharmacodynamics

Safety and Handling

• Handle with appropriate PPE (gloves, goggles)

• Use in ventilated areas to avoid inhalation

• Dispose of waste following institutional hazardous material protocols

Regulatory Status

• Controlled substance in many countries due to benzodiazepine classification

• Use restricted to research and forensic applications

• Verify local regulations before handling

Frequently Asked Questions (FAQs)

1. What is Norflurazepam?
   An active metabolite of several benzodiazepines with sedative and anxiolytic properties.

2. What is its chemical formula?
   C15H10ClFN2O.

3. How does it work?
   It enhances GABA-A receptor activity producing CNS depression.

4. What is its half-life?
   Long elimination half-life ranging from 47 to 150 hours.

5. How should it be stored?
   In a cool, dry, dark environment.

Conclusion

Norflurazepam is a long-acting benzodiazepine metabolite critical for understanding the pharmacology and toxicology of benzodiazepine medications. It requires careful handling in research and forensic laboratories with compliance to regulatory standards.