PRL-8-53

PRODUCT DESCRIPTION

Introduction

PRL-8-53 is a synthetic nootropic research chemical derived from benzoic acid and phenylmethylamine (benzylamine). It exists as a hydrochloride salt and appears as a white crystalline solid. PRL-8-53 was first synthesized in the 1970s and has been studied for its potential to enhance human memory and cognition. It is known for its hypermnesic properties, showing promising effects in improving memory recall in healthy individuals. The compound is primarily used for research into cognitive enhancement and related neuropharmacological mechanisms.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C18H22ClNO2C18H22ClNO2

• Molecular Weight: 319.83 g/mol

• CAS Number: 51352-87-5

• IUPAC Name: Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate hydrochloride

• Synonyms: PRL-8-53, PRL-8053, Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate hydrochloride, Benzoic acid, 3-[2-[methyl(phenylmethyl)amino]ethyl]-, methyl ester, hydrochloride

Physical Properties and Purity Standards

• Appearance: White crystalline solid

• Purity: Typically ≥98%

• Solubility:

  • DMF: 30 mg/mL

  • DMSO: 30 mg/mL

  • Ethanol: 30 mg/mL

  • PBS (pH 7.2): 10 mg/mL

• Storage Recommendations: Store sealed under inert gas (nitrogen or argon) at 2-8°C, away from moisture and light, preferably at -20°C for long-term storage.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

The exact mechanism of PRL-8-53 is not fully characterized but it is believed to exhibit cholinergic properties, potentiating dopamine release while partially inhibiting serotonin. It enhances memory and cognitive function by modulating neurotransmitter systems involved in learning and retention. PRL-8-53 has also demonstrated the ability to reverse reserpine-induced catatonia and ptosis in animal models.

Research Applications

PRL-8-53 is used in studies investigating cognitive enhancement, memory consolidation, and neurotransmitter modulation. It serves as a tool compound in neuropharmacological and behavioral research to explore novel nootropic mechanisms.

Comparative Analysis with Related Compounds

Compare to Related Compounds

PRL-8-53 differs from classic racetam nootropics as it is based on phenethylamine derivatives rather than pyrrolidone. It offers a unique cognitive enhancement profile by impacting dopamine and serotonin systems alongside cholinergic pathways.

Advantages for Research

Its high potency and rapid onset in memory improvement make it a valuable compound for investigating acute cognitive enhancement and neurotransmitter interactions.

Safety and Handling Guidelines

Laboratory Safety

Use gloves, lab coat, and eye protection. Avoid inhalation and skin contact. Handle in ventilated areas to reduce exposure.

Disposal and Environmental Considerations

Dispose of using hazardous chemical protocols; avoid environmental contamination.

Regulatory Status

Available only for research purposes. Not approved for human use or clinical applications.

Frequently Asked Questions (FAQs)

1. What is PRL-8-53 primarily used for?
   Nootropic research focused on memory and cognitive enhancements.

2. What doses have been studied?
   A single study used 5 mg administered orally 2-2.5 hours prior to cognitive tasks.

3. How should PRL-8-53 be stored?
   Store sealed at 2-8°C or -20°C under inert atmosphere.

4. Is PRL-8-53 soluble in water?
   Moderate solubility in PBS; better in DMSO, DMF, and ethanol.

5. Are there reported side effects?
   Limited toxicological data; no side effects reported in initial human studies at tested doses.

Conclusion

PRL-8-53 is a synthetic nootropic compound with promising memory-enhancing properties. Its distinct chemical structure and pharmacological effects make it important in cognitive neuroscience research, supported by high purity and stability under controlled storage.