Salvia divinorum Extract is a concentrated preparation derived from the leaves of the Salvia divinorum plant, a psychoactive herb native to Mexico. This extract contains higher concentrations of the active constituent salvinorin A compared to dried leaves, making it notably more potent for research and experimental use.

2. Chemical Composition & Structure

The primary active compound in Salvia divinorum Extract is salvinorin A (C23H28O8), a trans-neoclerodane diterpenoid and the most potent naturally occurring hallucinogen known. Unlike classical alkaloid psychedelics, salvinorin A is unique in being non-nitrogenous and acts as a selective kappa-opioid receptor (KOR) agonist. Extracts vary in concentration, typically measured in multiples (e.g., 10x, 25x) relative to raw leaves.

3. Research Applications

Salvia divinorum Extract is used in neuropharmacological and psychopharmacological research to investigate KOR mechanisms, hallucinogenic activity, potential analgesic effects, and neuropsychiatric applications. High potency extracts allow for precise dosing and exploration of dose-response relationships.

4. Recommended Laboratory Handling & Safety Guidelines

Use gloves and avoid inhalation or ingestion during handling. Store extracts in airtight, light-protected containers to prevent degradation. Work in well-ventilated areas, following institutional and safety protocols for potent psychoactive compounds.

5. Hazard Warnings & Risk Statements

Extracts are highly potent and can induce intense hallucinogenic effects. Careful labeling, secure storage, and controlled usage are essential to prevent accidental excessive exposure.

6. Compatibility with Other Substances

Limited data on interactions; avoid concurrent use with other CNS-active substances without supervision.

7. Emergency Protocols for Exposure

In case of overdose or adverse psychological effects, provide supportive care and seek medical attention.

8. Storage Stability & Shelf Life

Salvinorin A is chemically stable under dry, cool, and dark storage; extract shelf life depends on proper packaging and storage conditions.

9. Licensing & Purchase

Available for research use with regulatory compliance. Verify legal status before acquisition.

10. Legal Status for Online Purchase

Legal restrictions vary by jurisdiction; users must ensure compliance.

11. Laboratory Safety Measures

Standard PPE and containment procedures are required to safely handle high potency extracts.

12. Medical Considerations

Avoid use in those prone to psychiatric disorders without clinical oversight.

13. Allergen Exposure Risks

Minimal; gloves recommended.

14. Interaction with Other Chemicals

Use caution with other CNS-active and hallucinogenic substances.

15. Pregnancy Precautions

Not recommended.

16. Handling Consistency for Reproducibility

Maintain accurate records of extract concentration, storage, and handling to ensure experimental consistency.

17. Optimizing Research Outcomes

Use standardized extracts with validated salvinorin A content for reliable data.

18. Reported Pharmacological Effects

Strong kappa-opioid receptor agonism resulting in intense dissociation, hallucinations, and altered consciousness.

19. Known Adverse Effects

May include dysphoria, paresthesia, nausea, and psychological distress.

20. Severe Exposure Management

Emergency medical assistance required in adverse events.

21. Solvent Use

Extracts are often prepared using organic solvents like acetone or ethanol, avoiding water due to low solubility.

22. Research Scheduling

Strict dosing times improve reliability of results.

23. Recommended Storage Duration

Several years if stored properly in optimal conditions.

24. Post-Research Stability

Maintain dry, dark storage; dispose of degraded material responsibly.

25. Dependency or Sensitization Risk

Low physical dependence but strong psychological effects.

26. Long-Term Storage Recommendations

Store sealed, cool, and dark; desiccants may be used.

27. Alternative Extracts and Compounds

Other diterpenoid or traditional serotonergic psychedelics for comparative studies.