1D-LSD 150 MCG Blotters Product Description

Introduction

1D-LSD, also known as 1-(1,2-dimethylcyclobutane-1-carbonyl)-lysergic acid diethylamide, is a synthetic lysergamide and a novel LSD analog with a dimethylcyclobutane-1-carbonyl group attached at the nitrogen-1 position of the lysergic acid core. It is supplied as blotters impregnated with 150 micrograms of the compound, intended for scientific research and analytical purposes. This modification of the classic LSD structure results in a compound with potentially altered pharmacokinetic and pharmacodynamic properties, suitable for laboratory studies on psychedelic neuropharmacology.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C27H35N3O2

• Molecular Weight: Approximately 433.55 g/mol

• CAS Number: Not widely assigned (research chemical status)

• IUPAC Name: (8β)-1-(1,2-dimethylcyclobutane-1-carbonyl)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide

• Synonyms: 1D-LSD, 1-(1,2-dimethylcyclobutane-1-carbonyl)-LSD

Physical Properties and Purity Standards

• Appearance: Thin paper blotters impregnated with precise 150 microgram doses of 1D-LSD, typically colorless or lightly colored depending on the manufacturing process.

• Purity: ≥ 98% purity, meeting research-grade criteria for analytical validity.

• Solubility: Soluble in standard organic solvents such as ethanol, methanol, and acetonitrile; limited water solubility.

• Storage Recommendations: Store in sealed, light-resistant packaging in cool, dry environments, ideally refrigerated to prolong shelf life and prevent degradation.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

1D-LSD is a 5-HT2A receptor agonist and likely functions as a prodrug, metabolizing into LSD in vivo. This receptor subtype is crucial for the mediation of psychedelic effects. Animal model data and in vitro receptor assays indicate typical serotonergic psychedelic activity with altered potency and duration relative to LSD.

Research Applications

Widely used in neuropharmacology and psychedelic research, 1D-LSD enables study of receptor binding profiles, metabolism, and functional effects of acylated LSD derivatives. Its microdosed blotter format supports reproducible dosing studies for probing subtle neural effects and structure-activity relationships.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

Compared to LSD and analogs like 1B-LSD or 1cP-LSD, 1D-LSD has a bulkier cyclobutane carbonyl substituent at N1, influencing pharmacokinetics and receptor interaction. It shares core serotonergic activity with its analogs but may differ in onset, potency, and metabolic rate due to structural divergence.

Advantages for Research

1D-LSD’s unique N1-substitution provides new molecular insight into acyl-LSD prodrugs and receptor dynamics. The availability in 150 mcg blotters guarantees precise, straightforward dosing for pharmacological and behavioral studies.

Safety and Handling Guidelines

Laboratory Safety

Employ standard PPE including gloves, lab coat, and eye protection. Handle substances in well-ventilated areas or fume hoods. Avoid skin contact and inhalation.

Disposal and Environmental Considerations

Dispose according to hazardous chemical waste protocols. Ensure minimal environmental impact through proper containment and neutralization.

Regulatory Status

Subject to controlled substance regulations in multiple jurisdictions; intended exclusively for scientific research and not approved for human consumption.

Frequently Asked Questions (FAQs)

1. What dose does 1D-LSD blotters typically contain?

• Typically 150 micrograms per blotter for research dosing accuracy.

2. How pure is 1D-LSD?

• Generally > 98% pure, suitable for laboratory use.

3. Is 1D-LSD a prodrug to LSD?

• Yes, it is believed to metabolize into LSD in vivo.

4. What solvents dissolve 1D-LSD?

• Soluble in ethanol, methanol, acetonitrile; minimally soluble in water.

5. Is 1D-LSD legal for research?

• Legal restrictions vary; mostly restricted to licensed research only.

Conclusion

1D-LSD 150 MCG Blotters offer a high-purity, novel acylated LSD analog with precise dosing in blotter format. They are designed for research studying psychedelic pharmacology, receptor activity, and prodrug metabolism under strict laboratory and regulatory compliance.