2-FMA (2-Fluoromethamphetamine) Product Description

Introduction

2-Fluoromethamphetamine (2-FMA) is a synthetic stimulant and a fluorinated analog of methamphetamine. It features a fluorine atom attached at position 2 of the phenyl ring, altering its pharmacological profile compared to methamphetamine. 2-FMA is a regioisomer of 3-FMA and 4-FMA and is known for its stimulant properties affecting the central nervous system. It is primarily used in research to study stimulant mechanisms and neuropharmacology.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C10H14FN

• Molecular Weight: 167.22 g/mol

• CAS Number: 1780004-19-4

• IUPAC Name: 1-(2-fluorophenyl)-N-methylpropan-2-amine

• Synonyms: 2-Fluoromethamphetamine, 2-FMA

Physical Properties and Purity Standards

• Appearance: Typically a white to off-white crystalline powder.

• Purity: Research-grade substances commonly have purity levels ≥ 98%.

• Solubility: Soluble in organic solvents like ethanol, methanol, DMSO, DMF, and moderately soluble in water.

• Storage Recommendations: Store in airtight containers at temperatures below -20°C in a dry, dark place to preserve chemical stability.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

2-FMA acts by promoting the release and inhibiting the reuptake of dopamine, norepinephrine, and to a lesser extent serotonin, enhancing their extracellular concentrations in the brain. The fluorine substituent modifies its affinity and metabolic stability relative to methamphetamine, potentially altering potency and duration of stimulant effects.

Research Applications

This compound is used in laboratories to investigate the pharmacodynamics and pharmacokinetics of substituted methamphetamines, structure-activity relationships, and CNS stimulant effects. It serves as a valuable analytical standard and neurochemical probe.

Comparative Analysis with Related Compounds

Comparison with Related Compounds

2-FMA is a close analog of methamphetamine with a fluorine substituent that affects its biological interactions. It differs from positional isomers 3-FMA and 4-FMA in potency, metabolism, and receptor affinity. Compared to 2-FA, it has an additional methyl group on the amine nitrogen impacting pharmacodynamics.

Advantages for Research

Offers a distinct chemical structure to study the role of fluorination on stimulant pharmacology and metabolism. Facilitates comparative studies among fluorinated amphetamines and their physiological effects.

Safety and Handling Guidelines

Laboratory Safety

Use standard PPE such as gloves, lab coats, and eye protection. Handle in ventilated rooms or fume hoods to avoid inhalation and skin exposure.

Disposal and Environmental Considerations

Dispose according to hazardous chemical waste regulations. Prevent environmental contamination through proper waste management and chemical neutralization.

Regulatory Status

2-FMA is regulated or controlled in many areas due to abuse liability and is restricted to authorized research use only.

Frequently Asked Questions (FAQs)

1. What is 2-FMA used for in research?

• To study stimulant effects, neurochemical mechanisms, and metabolism of fluorinated amphetamines.

2. How does fluorination affect methamphetamine analogs?

• Enhances lipophilicity, potential CNS penetration, and metabolic stability.

3. What solvents dissolve 2-FMA?

• Ethanol, methanol, DMSO, DMF, and moderately in water.

4. How should 2-FMA be stored?

• Airtight containers below -20°C in dark, dry conditions.

5. Is 2-FMA legal?

• It is regulated as a controlled substance analog in many countries; research use only.

Conclusion

2-Fluoromethamphetamine (2-FMA) is a fluorinated methamphetamine analog with stimulant properties extensively used in research to explore neuropharmacology, stimulant mechanisms, and metabolic pathways. Safe handling and regulatory compliance are key to its laboratory use.