3-FPM 50 MG Pellets (3-Fluorophenmetrazine) Product Description

Introduction

3-Fluorophenmetrazine (3-FPM), also known as 3-FPM, PAL-593, or 3-FPH, is a synthetic stimulant from the phenylmorpholine chemical class. It is a fluorinated analogue of phenmetrazine, featuring a fluorine atom substituted at the 3-position of the phenyl ring. The compound exists as a white crystalline powder and is available in 50 mg pellets, designed for precise dosing in laboratory research contexts. 3-FPM is exclusively intended for scientific research purposes, with no approved therapeutic benefits.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder formulated into 50 mg pellets.

• Purity: Typically ≥ 98%, validated by chromatographic and spectrometric methods.

• Solubility: Soluble in organic solvents such as ethanol, methanol, DMSO; limited solubility in water.

• Storage Recommendations: Store in airtight containers under cool, dry, and dark conditions, preferably refrigerated between 2°C and 8°C to preserve stability and potency.

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

3-FPM is primarily a potent releaser of dopamine and norepinephrine, with negligible efficacy on serotonin release. It enters presynaptic neurons by reversing the function of dopamine (DAT) and norepinephrine (NET) transporters, increasing extracellular catecholamine levels and stimulating central nervous system activity. Its fluorine substitution increases lipophilicity and metabolic stability relative to phenmetrazine, enhancing stimulant potency.

Research Applications

Used extensively in neuropharmacology to investigate stimulant mechanisms, monoamine transporter interaction, and abuse potential. 3-FPM supports structure-activity relationship studies of fluorinated phenylmorpholines and aids forensic toxicology in identifying novel psychoactive substances.

Comparative Analysis with Related Compounds

Comparison to 2-FPM and 4-FPM

3-FPM differs from 2-FPM and 4-FPM by its fluorine atom’s position on the aromatic ring. It exhibits intermediate potency and unique uptake inhibition profiles compared to these positional isomers. 3-FPM generally shows less serotonergic but strong dopaminergic and noradrenergic activity, shaping its stimulant profile differently.

Advantages for Research

• Pure, well-characterized compound suitable for detailed transporter and receptor studies.

• Allows examination of fluorination effects on stimulant pharmacodynamics.

• Supports advanced forensic methodology and toxicological research.

Safety and Handling Guidelines

Laboratory Safety

Always use personal protective equipment including gloves, lab coats, and eye protection. Handle under fume hoods or in well-ventilated labs to reduce exposure risks.

Disposal and Environmental Considerations

Ensure proper disposal per hazardous chemical protocols, safeguarding the environment through containment.

Regulatory Status

Regulated as a research chemical with restrictions on use. Authorized only for scientific and laboratory purposes.

Frequently Asked Questions (FAQs)

1. How does 3-FPM act pharmacologically?

• Mainly by releasing dopamine and norepinephrine with negligible serotonin activity.

2. What purity is expected for research-grade 3-FPM?

• Generally ≥ 98% purity.

3. Which solvents dissolve 3-FPM?

• Ethanol, methanol, DMSO; limited water solubility.

4. How does 3-FPM compare to other fluorophenmetrazines?

• Its fluorine position alters transporter selectivity, influencing stimulant potency.

5. Is 3-FPM legal?

• It is controlled and restricted to licensed scientific research contexts.

Conclusion

3-FPM 50 MG Pellets feature a high-purity fluorinated stimulant phenylmorpholine compound valuable for neuroscience and forensic research. Their dopaminergic and noradrenergic releaser activity, alongside excellent chemical characterization, supports cutting-edge studies on novel psychoactive substances.