4-AcO-DET 20mg Pellets Product Description

Introduction

4-AcO-DET (4-Acetoxy-N,N-diethyltryptamine) is a synthetic psychedelic tryptamine analog closely related to psilocybin and psilocin, acting as a prodrug that metabolizes into the active compound 4-HO-DET. It is structurally characterized by an acetoxy group at the 4-position of the indole ring and two ethyl groups on the amine terminal. 4-AcO-DET produces psychedelic effects including visual hallucinations, alterations in perception, and mood enhancement. Pellets containing 20 mg are designed for precise dosage in scientific and psychopharmacological research.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White crystalline powder formulated into 20 mg pellets.

• Purity: Research-grade purity ≥ 98%, confirmed by chromatographic and spectroscopic methods.

• Solubility: Soluble in ethanol (20 mg/mL), dimethyl sulfoxide (DMSO, 10 mg/mL), dimethylformamide (DMF, 30 mg/mL).

• Storage Recommendations: Store at -20°C in airtight, light-resistant containers to ensure stability. Stock solutions should be aliquoted and stored appropriately to avoid repeated freeze-thaw cycles.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4-AcO-DET acts primarily as a serotonin receptor agonist, especially at the 5-HT2A receptor, mediating its psychedelic effects. It is a prodrug converted in vivo to 4-HO-DET, which binds serotonin receptors and leads to altered perception, cognition, and mood enhancement. Effects typically last 4-6 hours orally, with onset within 20-45 minutes.

Research Applications

Used in preclinical and clinical research to study serotonin receptor pharmacodynamics and psychedelic mechanisms. It also helps in comparative research of tryptamine derivatives and prodrugs for hallucinogenic compounds.

Dosage and Effects

• Typical oral dose: 10-25 mg for psychoactive effects; 20 mg pellets provide a precise researcher-friendly dosage.

• Duration: 4-6 hours with onset at 20-45 minutes.

• Effects: Visual and auditory hallucinations, intensified sensory experiences, mood alteration, and enhanced introspection.

Safety and Handling Guidelines

Laboratory Safety

Use gloves, lab coat, and eye protection during handling. Prepare solutions in ventilated areas or fume hoods to minimize exposure.

Disposal and Environmental Considerations

Dispose of chemical waste per hazardous substances guidelines. Prevent environmental contamination.

Regulatory Status

4-AcO-DET is a controlled research chemical subject to regulations restricting use to licensed scientific research.

Frequently Asked Questions (FAQs)

1. What is the active form of 4-AcO-DET?

• 4-AcO-DET is a prodrug that metabolizes to 4-HO-DET, the active psychedelic compound.

2. What receptors does 4-AcO-DET affect?

• Primarily serotonin 5-HT2A receptors.

3. How soluble is 4-AcO-DET?

• Soluble in ethanol, DMSO, and DMF at concentrations suitable for research.

4. What is the usual dose range for 4-AcO-DET?

• Typically 10-25 mg orally.

5. Is 4-AcO-DET legal?

• It is regulated and restricted to scientific research.

Conclusion

4-AcO-DET 20mg pellets are high-purity, precisely dosed research chemicals used to study serotonin receptor-mediated psychedelic effects through their metabolism to 4-HO-DET. They provide a valuable tool for neuropharmacological and behavioral research on novel tryptamine psychedelics.