4-FMA (4-Fluoromethamphetamine) Pure Product Description

Introduction

4-Fluoromethamphetamine (4-FMA) is a synthetic stimulant closely related to methamphetamine and 4-fluoroamphetamine. It is used predominantly as a research chemical with stimulant and empathogenic effects resulting from monoamine releasing properties. Pure 4-FMA is typically supplied as a high-purity crystalline hydrochloride salt for laboratory use in neuropharmacology, toxicology, and forensic studies.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Purity Standards

• Appearance: White crystalline powder.

• Purity: Research-grade purity ≥ 98%, confirmed by chromatography and spectroscopy.

• Solubility: Soluble at 30 mg/mL in DMF, DMSO, ethanol, and 10 mg/mL in phosphate-buffered saline (pH 7.2).

• Storage Recommendations: Store at -20°C tightly sealed and protected from light.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

4-FMA acts as a potent releasing agent for serotonin, dopamine, and norepinephrine, contributing to its stimulant and empathogenic effects. It also inhibits CYP450 enzymes, modulating the metabolism and toxicity profile of substances with which it is co-administered.

Research Applications

Used for preclinical and toxicological research, behavioral pharmacology, and as a reference standard in forensic drug analysis.

Safety and Handling Guidelines

Laboratory Safety

Handle with appropriate PPE—gloves, lab coat, eye protection—and in ventilated conditions or fume hoods to minimize exposure.

Disposal and Environmental Considerations

Dispose of as hazardous chemical waste per regulatory standards.

Regulatory Status

4-FMA is a controlled substance in numerous countries and restricted to authorized research use.

Frequently Asked Questions (FAQs)

1. What is 4-FMA chemically?

• A fluorinated analog of methamphetamine with stimulant and empathogenic effects.

2. What purity is standard for pure 4-FMA?

• Typically ≥ 98% in research-grade materials.

3. What are the main solvents for 4-FMA?

• DMF, DMSO, ethanol, and phosphate-buffered saline.

4. How is 4-FMA stored?

• Stored at -20°C in airtight and light-protected containers.

5. Is 4-FMA legal?

• Controlled substance restricted to licensed scientific use.

Conclusion

Pure 4-FMA hydrochloride is a high-purity, stable, crystalline stimulant useful for rigorous scientific research. Its pharmacokinetic and pharmacodynamic profiles make it a key compound in stimulant and empathogen pharmacological studies.