5-MAPB Product Description

Introduction

5-MAPB (1-(benzofuran-5-yl)-N-methylpropan-2-amine) is a synthetic entactogenic and stimulant research chemical structurally related to the benzofuran and amphetamine class of compounds. It features a benzofuran ring attached at the 5-position to an N-methylpropaneamine side chain. 5-MAPB is known for its serotonin receptor agonism and dopamine reuptake inhibition, producing empathogenic and stimulant effects similar to MDMA. It is widely studied in neuropharmacology and forensic toxicology.

Chemical Properties and Specifications

Structural and Molecular Characteristics

Physical Properties and Solubility

• Appearance: White to off-white crystalline powder or solid.

• Solubility: Soluble in dimethylformamide (DMF), DMSO, ethanol, methanol, and phosphate buffered saline (PBS).

• Purity: Research-grade purity typically ≥ 98%.

• Storage: Store in airtight, light-shielded containers at cool temperatures (-20°C) to preserve stability.

Pharmacological Profile and Mechanism of Action

Mechanism of Action

5-MAPB acts as a serotonin receptor agonist and inhibitor of dopamine reuptake, affecting neurotransmitters serotonin, dopamine, and norepinephrine. Its binding mode overlaps with that of MDMA and related compounds and induces entactogenic, euphoric, and stimulant effects. Molecular docking and dynamic studies support its stabilizing interactions with dopamine transporters.

Research Applications

Used extensively in laboratory and forensic research to understand stimulant and empathogenic effects, receptor binding, metabolic pathways, and toxicological profiles of novel psychoactive substances.

Safety and Handling Guidelines

Laboratory Safety

Wear gloves, lab coat, and eye protection. Perform work in ventilated environments or fume hoods.

Disposal and Environmental Considerations

Dispose of chemical waste appropriately per hazardous material regulations.

Regulatory Status

5-MAPB is controlled or regulated in various jurisdictions and should be restricted to authorized research use.

Frequently Asked Questions (FAQs)

1. What is 5-MAPB chemically?

• A benzofuran derivative with an N-methylpropaneamine side chain.

2. What receptors does it target?

• Serotonin receptors and dopamine transporters.

3. What purity is typical?

• Research-grade purity around ≥ 98%.

4. How soluble is 5-MAPB?

• Soluble in typical organic solvents and buffered saline.

5. Is 5-MAPB legal?

• Controlled substance in many countries, research only.

Conclusion

5-MAPB is a stable, high-purity benzofuran-entactogen research chemical with relevant pharmacological and toxicological characteristics important for neuropharmacology and forensic science.