Bromazolam 2.5mg Pellets

PRODUCT DESCRIPTION

Introduction

Bromazolam is a triazolo-benzodiazepine, structurally related to alprazolam with a bromine atom replacing chlorine. It acts as a potent benzodiazepine receptor agonist with anxiolytic, sedative, and muscle relaxant effects. Bromazolam 2.5mg pellets provide a controlled, standardized dosage form intended for research in neuropharmacology and behavioral studies.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H13BrN4

• Molecular Weight: 353.22 g/mol

• CAS Number: 71368-80-4

• IUPAC Name: 8-Bromo-1-methyl-6-phenyl-4H-triazolo[4,3-a]benzodiazepine

• Synonyms:

  • Bromazolam

  • XLI-268

2.2 Physical Properties and Purity Standards

• Appearance: White to light cream crystalline pellets

• Dosage Strength: 2.5 mg per pellet

• Purity: ≥98% pharmaceutical grade purity

• Solubility: Soluble in dimethylformamide (30 mg/mL), dimethyl sulfoxide (20 mg/mL), ethanol (10 mg/mL), methanol (1 mg/mL), and aqueous mixtures with solvents

• Melting Point: Between 272.0–275 °C

• Storage Recommendations: Store sealed at 4°C to -20°C, protected from light and moisture

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Bromazolam is a benzodiazepine receptor agonist that binds non-selectively at GABA-A receptor sites. It enhances GABAergic inhibitory neurotransmission, yielding anxiolytic, sedative, and muscle-relaxant effects similar to alprazolam but with distinct potency and pharmacokinetics due to bromine substitution.

3.2 Research Applications

Utilized in receptor binding assays, behavioral studies, and pharmacokinetic profiling, bromazolam pellets are essential for investigating novel benzodiazepine derivatives. The 2.5 mg dosage supports dose-response studies and toxicity evaluations.

Comparative Analysis with Related Compounds

4.1 Compared to Alprazolam and Other Benzodiazepines

Bromazolam resembles alprazolam in structure and action but generally exhibits different pharmacokinetics and potency. Compared to other designer benzodiazepines (e.g., flubromazolam, pyrazolam), bromazolam offers a unique binding affinity to different GABA-A subunits.

4.2 Advantages for Research

Pellet form ensures dosage accuracy, ease of handling, and stability. Enables robust pharmacological characterization and toxicology studies.

Safety and Handling Guidelines

5.1 Laboratory Safety

Wear PPE including gloves, lab coat, and eye protection. Use in a well-ventilated area or fume hood. Prevent inhalation and skin contact.

5.2 Disposal

Follow hazardous waste disposal regulations to prevent environmental contamination.

5.3 Regulatory Status

Bromazolam is controlled or regulated in numerous jurisdictions. Researchers must verify regional legal status before acquisition and use.

Frequently Asked Questions (FAQs)

1. What is bromazolam?
   A benzodiazepine analog similar to alprazolam with bromine substitution.

2. What dosage does bromazolam pellet contain?
   2.5 mg per pellet.

3. What are its main effects?
   Anxiolytic, sedative, and muscle relaxant effects.

4. Is bromazolam soluble in water?
   Poorly soluble; better dissolved in organic solvents.

5. Is bromazolam regulated?
   Yes, regulated in many countries as a controlled substance.

Conclusion

Bromazolam 2.5 mg pellets are a high-purity benzodiazepine research chemical useful for neuropharmacological studies involving anxiolytic and sedative agents. Their standardized dosage and physicochemical properties support well-controlled experimental usage with essential safety and regulatory compliance.