Etizolam 1mg Blotters Product Description

Introduction

Etizolam 1mg blotters are thin pieces of absorbent paper infused with Etizolam, a thienodiazepine class compound closely related to benzodiazepines. Etizolam exhibits anxiolytic, sedative, muscle relaxant, and hypnotic properties. The blotter form allows for rapid absorption through oral mucosa or ingestion, facilitating precise dosing in research contexts. Etizolam blotters typically contain 1 milligram of the active compound per piece and are typically white or lightly colored.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H15ClN4S

• Molecular Weight: 342.84 g/mol

• CAS Number: 40054-69-1

• IUPAC Name: 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepine

• Synonyms: Etizolam, Etilaam, Thienodiazepine, Etizest

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder infused on blotters

• Purity: Typically ≥99% pharmaceutical grade for blotters preparation

• Solubility: Slightly soluble in water; soluble in alcohol and organic solvents used in blotter preparation

• Storage Recommendations: Store in a cool, dry, and dark place in airtight packaging to preserve potency and prevent degradation

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Etizolam functions as a positive allosteric modulator of the GABA-A receptor by binding to benzodiazepine sites, enhancing the effect of the inhibitory neurotransmitter GABA. This leads to neuronal hyperpolarization that manifests as anxiolytic, sedative, muscle relaxant, and anticonvulsant effects. Etizolam’s effects onset rapidly, typically within 30-60 minutes, and duration lasts approximately 6-8 hours.

3.2 Research Applications

Etizolam blotters are used in preclinical and pharmacological research to study benzodiazepine receptor pharmacodynamics, GABAergic mechanisms, and anxiolytic compound development. They provide a reproducible and convenient dosage form for examining dose-response relationships and pharmacokinetics.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

Compared to classic benzodiazepines like diazepam, etizolam is more potent on a per milligram basis, with a shorter half-life allowing for quicker elimination and less accumulation. Etizolam’s thienodiazepine structure imparts distinct pharmacokinetics and receptor affinity profiles relative to benzodiazepines. The blotter form differs by offering rapid onset absorption compared to tablets or capsules.

4.2 Advantages for Research

Blotters allow precise dosing and rapid absorption for accurate pharmacokinetic evaluations. The 1mg strength provides a standard measurable unit, facilitating consistent and comparable research data. The formulation also reduces variability due to administration method differences.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use protective gloves and eyewear when handling etizolam blotters. Avoid inhalation of dust or vapor. Handle in a well-ventilated chemical laboratory environment with appropriate containment.

5.2 Disposal and Environmental Considerations

Dispose of unused blotters and waste materials according to institutional hazardous chemical waste guidelines. Avoid environmental contamination.

5.3 Regulatory Status

Etizolam is a controlled substance in many jurisdictions due to its potent CNS effects and potential for abuse. It is approved only for research use in regulated laboratory environments. Researchers must comply with all relevant legal restrictions.

Frequently Asked Questions (FAQs)

1. What dose of Etizolam is in each blotter?
   Typically 1 milligram per blotter.

2. How quickly does Etizolam act from blotters?
   Effects typically begin within 30-60 minutes.

3. What effects does Etizolam produce?
   Anxiolysis, sedation, muscle relaxation, and anticonvulsant effects.

4. How long do effects last?
   Approximately 6 to 8 hours depending on dose and metabolism.

5. What precautions are there handling Etizolam blotters?
   Use PPE, avoid inhalation or gloves contact, store securely.

Conclusion

Etizolam 1mg blotters provide a precise, rapidly absorbed form of a potent thienodiazepine for research into GABAergic CNS modulation. Their reproducibility, rapid onset, and controlled dosing make them ideal for pharmacological and neuroscientific investigation.