Etizolam Pure Product Description

Introduction

Etizolam is a synthetic thienodiazepine commonly used as an anxiolytic, sedative, muscle relaxant, and hypnotic agent in research settings. Chemically related to benzodiazepines, it differs by having a thiophene ring replacing the benzene ring in classic benzodiazepines. Pure Etizolam is typically available as a white to off-white crystalline powder used in pharmaceutical and biochemical research. It demonstrates strong affinity for the GABA-A receptor complex, modulating inhibitory neurotransmission in the central nervous system.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H15ClN4S

• Molecular Weight: 342.85 g/mol

• CAS Number: 40054-69-1

• IUPAC Name: 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepine

• Synonyms: Etizolam, Etilaam, Thienodiazepine

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Purity: Typically ≥98% pharmaceutical/research grade

• Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and DMSO

• Storage Recommendations: Store in airtight containers in a cool, dry place protected from light to prevent degradation

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Etizolam acts as a potent positive allosteric modulator of the GABA-A receptor by binding to benzodiazepine sites, enhancing the inhibitory action of GABA neurotransmitter. This leads to sedative, anxiolytic, muscle relaxant, and anticonvulsant effects. Etizolam demonstrates approximately 6 to 10 times greater potency than diazepam and has a relatively short half-life favorable for research.

3.2 Research Applications

Etizolam is widely used in pharmacological studies investigating GABAergic neurotransmission modulation, anxiolytic drug development, receptor binding assays, and neuropharmacology research models. Its well-characterized pharmacology makes it a preferred model compound for benzodiazepine-like CNS depressants.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

Compared to diazepam and other classical benzodiazepines, Etizolam has a different chemical scaffold yet binds similarly to GABA-A receptors. It differs with a faster onset of action and shorter duration. These factors make Etizolam advantageous for experimental models requiring tight temporal control.

4.2 Advantages for Research

High purity and chemical stability allow reproducible results. Its high potency permits low dose studies, reducing confounding factors. Etizolam’s unique thienodiazepine structure offers insights distinct from traditional benzodiazepines in receptor interaction studies.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use gloves, safety goggles, and lab coats when handling Etizolam powder. Employ adequate ventilation and avoid inhalation or skin contact.

5.2 Disposal and Environmental Considerations

Dispose of according to chemical hazardous waste protocols. Prevent environmental contamination through proper waste management.

5.3 Regulatory Status

Etizolam is regulated under controlled substance schedules in many jurisdictions. It is strictly for research use and not approved for human therapeutic consumption by regulatory agencies such as the FDA.

Frequently Asked Questions (FAQs)

1. What is the molecular weight of Etizolam?
   342.85 g/mol.

2. What receptors does Etizolam primarily target?
   The GABA-A receptor benzodiazepine site.

3. How pure is pharmaceutical-grade Etizolam?
   Typically ≥98%.

4. What are common research uses of Etizolam?
   Studying anxiolytics, sedatives, GABA receptor pharmacology, CNS depression.

5. How should Etizolam be stored?
   In a cool, dry, dark place protected from moisture and light.

Conclusion

Etizolam pure crystalline powder is a high-potency thienodiazepine research chemical targeting GABA-A receptor complexes. Its pharmacological profile, high purity, and stability make it ideal for in-depth neuropharmacological and anxiolytic research.