Flmodafinil (CRL-40,940) Product Description

Introduction

Flmodafinil, also known as CRL-40,940, bisfluoromodafinil, or lauflumide, is a potent eugeroic (wakefulness-promoting agent) and nootropic compound. It is a fluorinated analog of modafinil, featuring two fluorine atoms substituted on its phenyl rings. Flmodafinil is designed to enhance cognitive function, wakefulness, and motivation, with claimed improved potency, metabolic stability, and fewer side effects compared to modafinil. It is typically a white to off-white crystalline powder used in pharmaceutical research and preclinical studies.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H13F2NO2S

• Molecular Weight: 309.33 g/mol

• CAS Number: 90280-13-0

• IUPAC Name: 2-(bis(4-fluorophenyl)methyl)sulfinylacetamide

• Synonyms: Flmodafinil, CRL-40,940, bisfluoromodafinil, lauflumide

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Melting Point: 78-80°C

• Boiling Point: 558.7 ± 50.0°C (predicted)

• Density: 1.397 ± 0.06 g/cm³ (predicted)

• Purity: Typically ≥99% pharmaceutical/research grade

• Solubility: Highly soluble in DMSO (~100 mg/mL); soluble in polar organic solvents

• Storage Recommendations: Store at -20°C in airtight containers, protected from moisture and light

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Flmodafinil acts primarily by inhibiting dopamine reuptake transporters (DAT), increasing extracellular dopamine concentrations. It also influences other neurotransmitter systems to promote wakefulness and cognitive enhancement. Flmodafinil’s fluorinated structure enhances metabolic stability and blood-brain barrier penetration, contributing to improved potency and duration of action compared to modafinil.

3.2 Research Applications

Flmodafinil is widely applied in pharmacological and neuroscientific studies evaluating wakefulness-promoting mechanisms, cognitive enhancement, and dopamine transporter modulation. It is of significant interest for therapeutic research in conditions like chronic fatigue syndrome, idiopathic hypersomnia, and attention deficit hyperactivity disorder (ADHD).

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

Flmodafinil differs from modafinil by adding two fluorine atoms on the phenyl rings, which increases potency and metabolic resistance. Compared to armodafinil and esmodafinil, it offers different enantiomeric profiles and potentially longer-lasting effects. Flmodafinil has demonstrated enhanced efficacy and fewer side effects in preliminary studies.

4.2 Advantages for Research

Its high purity and solubility support reproducible dosing and formulation. Enhanced blood-brain barrier penetration and metabolic stability make it valuable for cognitive and wakefulness studies. The compound’s clinical trial status offers translational research potential.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use gloves, protective eyewear, and lab coats when handling Flmodafinil powder. Perform work in well-ventilated environments or fume hoods. Avoid inhalation, ingestion, and skin contact.

5.2 Disposal and Environmental Considerations

Dispose of according to institutional hazardous chemical regulations. Prevent environmental contamination.

5.3 Regulatory Status

Flmodafinil is a research chemical with investigational drug status. It is not approved for general medical use and is subject to regulatory controls in various regions. Adherence to all applicable laws and research guidelines is mandatory.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of Flmodafinil?
   C15H13F2NO2S.

2. What is the CAS number for Flmodafinil?
   90280-13-0.

3. How soluble is Flmodafinil?
   Highly soluble in DMSO (~100 mg/mL); soluble in polar organic solvents.

4. What pharmacological effects does Flmodafinil produce?
   Wakefulness promotion, cognitive enhancement, dopamine transporter inhibition.

5. What are typical research applications of Flmodafinil?
   Neuropharmacology, wakefulness studies, ADHD research, cognitive enhancement.

Conclusion

Flmodafinil (CRL-40,940) is a high-potency, fluorinated modafinil analog that promotes wakefulness and cognitive enhancement through dopamine transporter inhibition. Its enhanced stability and efficacy profile make it a valuable compound in pharmaceutical and neuroscience research.