Flmodafinil – Solution Product Description

Introduction

Flmodafinil, also known as BisfluoroModafinil or CRL-40,940, is a fluorinated derivative of modafinil, a well-known wakefulness-promoting agent. Chemically, Flmodafinil contains two fluorophenyl rings attached to a sulfinyl-acetamide core, contributing to its potent pharmacological profile. It is typically supplied as a clear solution for research purposes, facilitating development and pharmacokinetic studies on wakefulness and cognitive enhancement.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C15H13F2NO2S

• Molecular Weight: 309.33 g/mol

• CAS Number: 90280-13-0

• IUPAC Name: 2-(bis(4-fluorophenyl)methyl)sulfinylacetamide

• Synonyms: Flmodafinil, BisfluoroModafinil, CRL-40,940, Lauflumide

2.2 Physical Properties and Purity Standards

• Appearance: Clear solution (when dissolved appropriately) or white to off-white solid powder

• Purity: Typically ≥99% (pharmaceutical/research grade)

• Solubility: Highly soluble in DMSO (100 mg/mL), soluble in polar solvents; preparation in aqueous solutions requires suitable co-solvents for clarity

• Storage Recommendations: Store solution in amber glass vials, refrigerated (2-8°C), avoid light and moisture

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Flmodafinil acts as a wakefulness-promoting agent similar to modafinil but with enhanced potency and longer duration. It functions primarily by inhibiting dopamine reuptake transporters (DAT), leading to increased extracellular dopamine levels and improved cognitive alertness. Its fluorinated structure increases metabolic stability and blood-brain barrier permeability.

3.2 Research Applications

Flmodafinil solution is utilized extensively in neuropharmacology research on wakefulness, cognitive enhancement, and stimulant mechanisms. Its formulation as a solution enables precise dosing for in vitro assays, pharmacokinetic studies, and in vivo experiments involving administration through various routes.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

Compared to modafinil, Flmodafinil has enhanced potency and metabolic stability. Unlike modafinil’s racemic mixture, flmodafinil offers improved receptor binding profiles due to its fluorine substitutions. It stands out among eugeroics for its unique pharmacokinetic properties and prolonged activity.

4.2 Advantages for Research

The solution format allows for versatile experimental application and dosage control. High purity ensures reproducibility and consistency in biochemical and pharmacological research. Superior metabolic stability aids in the exploration of novel stimulant therapies and cognitive enhancers.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use gloves, lab coat, and eye protection when handling flmodafinil solutions. Work in a ventilated area, preferably within fume hoods. Avoid ingestion, inhalation, and skin contact.

5.2 Disposal and Environmental Considerations

Dispose of waste solution in accordance with hazardous chemical disposal protocols. Prevent environmental contamination.

5.3 Regulatory Status

Flmodafinil is a research chemical classified for experimental purposes only. Next-stage pharmaceutical applications are under investigation, with regulatory status varying by jurisdiction.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of Flmodafinil?
   C15H13F2NO2S.

2. How soluble is Flmodafinil?
   Highly soluble in DMSO (100 mg/mL); soluble in other polar solvents.

3. What is Flmodafinil’s mechanism of action?
   Inhibition of dopamine reuptake transporter, promoting wakefulness.

4. What are common research uses?
   Studies on cognitive enhancement, stimulant pharmacology, and wakefulness.

5. How should Flmodafinil solution be stored?
   Refrigerated (2-8°C), in amber glass, protected from light.

Conclusion

Flmodafinil solution is a potent, fluorinated modafinil analog utilized in research focused on cognitive and wakefulness enhancement. Its high purity, solubility, and stability make it ideal for pharmacological studies and drug development research.