Flualprazolam 1mg Pellets Product Description

Introduction

Flualprazolam is a high-potency triazolobenzodiazepine, structurally related to alprazolam but with enhanced activity due to fluorination. It exhibits strong sedative, anxiolytic, muscle relaxant, and hypnotic effects. Flualprazolam 1mg pellets are solid dosage forms designed for precise administration in research settings. These pellets help ensure accurate dosing in experimental models studying benzodiazepine receptor pharmacology.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H12ClFN4

• Molecular Weight: 326.76 g/mol

• CAS Number: 28910-91-0

• IUPAC Name: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-triazolo[4,3-a]benzodiazepine

• Synonyms: Flualprazolam, fluorinated alprazolam, FLUALPRAZOLAM CRM

2.2 Physical Properties and Pellet Specifications

• Appearance: White or off-white small pellets

• Solubility: Soluble in organic solvents such as DMSO, ethanol, methanol; not highly water-soluble

• Dosage: Each pellet contains 1 mg of Flualprazolam

• Storage Recommendations: Store in a cool, dry, dark place in airtight containers to maintain stability

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Flualprazolam acts as a potent positive allosteric modulator of the GABA-A receptor at benzodiazepine binding sites. This leads to enhanced GABAergic inhibition of neuronal activity resulting in sedative and anxiolytic effects. The compound shows increased receptor affinity and potency relative to alprazolam.

3.2 Research Applications

Used primarily in neuroscientific and pharmacological research to study benzodiazepine receptor binding, pharmacokinetics, and the impact of benzodiazepines on CNS functions. The pellet format allows precise dose control in in vivo and in vitro models.

Comparative Analysis with Related Compounds

4.1 Comparison with Alprazolam and Other Benzodiazepines

Flualprazolam is more potent than alprazolam due to the fluorine atom enhancing binding affinity. It has a similar mechanism but with potentially longer duration and stronger effects, making it suitable for research into high-potency benzodiazepines.

4.2 Advantages for Research

Pellets provide uniform dose delivery and minimize measurement errors common with powder forms. The 1mg dosage is optimal for a wide range of research applications requiring fine dose adjustments.

Safety and Handling Guidelines

5.1 Laboratory Safety

Handle pellets using gloves, lab coat, and eye protection. Work in well-ventilated areas or fume hoods. Avoid inhalation and direct skin contact.

5.2 Disposal and Environmental Considerations

Dispose of according to hazardous chemical disposal protocols. Prevent environmental contamination.

5.3 Regulatory Status

Flualprazolam is a controlled substance in many countries, used exclusively for research purposes under strict regulatory oversight. Compliance with local laws is mandatory.

Frequently Asked Questions (FAQs)

1. What is the dosage per Flualprazolam pellet?
   1 mg per pellet.

2. What is Flualprazolam’s chemical formula?
   C17H12ClFN4.

3. How does Flualprazolam compare to Alprazolam?
   It is more potent and fluorinated, with higher receptor affinity.

4. What solvents dissolve Flualprazolam pellets?
   DMSO, ethanol, methanol; limited water solubility.

5. What is the primary research use?
   Studying high potency benzodiazepine pharmacology and CNS effects.

Conclusion

Flualprazolam 1mg pellets offer a potent, standardized dosage form of a fluorinated benzodiazepine suitable for detailed CNS receptor pharmacology research. Their precise dosing, stability, and pharmacological profile make them essential in high-potency benzodiazepine studies.