Fluetizolam 1 mg Pellets Product Description

Introduction

Fluetizolam is a potent thienotriazolodiazepine benzodiazepine analog structurally related to etizolam. Known for its strong sedative, anxiolytic, and muscle relaxant effects, Fluetizolam is a valuable compound in neuropharmacological research. The 1 mg pellet form offers precise, measured dosing suitable for in vivo and in vitro studies, enabling consistent administration and reliable experimental outcomes.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H15FN4S

• Molecular Weight: 326.39 g/mol

• CAS Number: 40054-88-4

• IUPAC Name: 2-ethyl-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepine

• Synonyms: Fluetizolam, 2′-Fluorodeschloroetizolam

2.2 Physical Properties and Pellet Specifications

• Appearance: White to off-white solid pellets

• Dosage: 1 mg per pellet

• Purity: Typically ≥98% pharmaceutical/research grade

• Solubility: Soluble in DMSO (~3 mg/mL), DMF (~5 mg/mL), ethanol (~5 mg/mL); insoluble in phosphate-buffered saline (pH 7.2)

• Storage Recommendations: Store in airtight containers at -20°C for long-term stability; protect from moisture and light

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Fluetizolam modulates GABA-A receptors as a high-affinity positive allosteric modulator at benzodiazepine sites. This action enhances GABA’s inhibitory effects, producing sedation, anxiolysis, muscle relaxation, and hypnotic effects. The compound’s fluorinated thieno structure contributes to potent receptor binding and effects.

3.2 Research Applications

Ideal for research in benzodiazepine receptor pharmacology, CNS depressant actions, and behavioral studies. Pellets ensure dose uniformity for reliable pharmacodynamic and toxicological investigations.

Comparative Analysis with Related Compounds

4.1 Comparison with Etizolam and Other Benzodiazepines

Fluetizolam offers higher potency and prolonged effects compared to etizolam due to a unique fluorine substitution and thieno ring system. It assists in studying potent benzodiazepine analogs with distinct pharmacokinetics.

4.2 Advantages for Research

Pellet dosage forms provide ease of use and precise dosing, reducing variability common with powders. Enables wide-ranging applications from mechanistic studies to behavioral assays.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use gloves, lab coat, and safety glasses. Perform handling in a well-ventilated area or fume hood to prevent exposure by inhalation or skin contact.

5.2 Disposal and Environmental Considerations

Dispose of materials as hazardous waste following local regulations.

5.3 Regulatory Status

Fluetizolam is a controlled research chemical. Usage must comply with local legislation and institutional policies.

Frequently Asked Questions (FAQs)

1. What is the dosage per Fluetizolam pellet?
   1 mg.

2. What is Fluetizolam’s molecular formula?
   C17H15FN4S.

3. How soluble is Fluetizolam?
   Soluble in DMSO, DMF, ethanol; not soluble in PBS.

4. What receptor does Fluetizolam modulate?
   GABA-A receptor benzodiazepine binding site.

5. What are typical uses in research?
   Studying benzodiazepine receptor pharmacology and CNS depressant mechanisms.

Conclusion

Fluetizolam 1 mg pellets provide a high-purity, potent benzodiazepine analog dosage form for neuropharmacological research. Their chemical stability and standardized dosing enable accurate and reproducible scientific investigations.