Fluetizolam 1 mg Pellets Product Description

Introduction

Fluetizolam is a potent thienodiazepine benzodiazepine analog with sedative, anxiolytic, muscle relaxant, and hypnotic properties. The 1 mg pellet form delivers precise dosing suitable for pharmaceutical and neuropharmacological research. Its fluorinated thieno structure enhances receptor binding affinity and potency, making Fluetizolam a valuable compound for studies into GABA-A receptor modulation and CNS effects.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C17H15FN4S

• Molecular Weight: 326.39 g/mol

• CAS Number: 40054-88-4

• IUPAC Name: 2-ethyl-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepine

• Synonyms: Fluetizolam, 2′-Fluorodeschloroetizolam

2.2 Physical Properties and Pellet Specifications

• Appearance: White to off-white solid pellets

• Dosage: 1 mg per pellet

• Purity: Typically ≥98% pharmaceutical/research grade

• Solubility: Soluble in DMSO (~3 mg/mL), DMF (~5 mg/mL), ethanol (~5 mg/mL); insoluble in phosphate-buffered saline (pH 7.2)

• Storage Recommendations: Store in airtight containers at -20°C to protect from moisture, light, and degradation

Pharmacological Profile and Mechanism of Action

3.1 Mechanism of Action

Fluetizolam acts as a high-affinity positive allosteric modulator at benzodiazepine binding sites of the GABA-A receptor. This increases the receptor’s inhibitory effects leading to CNS depression characterized by sedation, anxiolysis, muscle relaxation, and hypnotic effects. Its chemical structure contributes to enhanced potency compared to many benzodiazepines.

3.2 Research Applications

Used in research focused on benzodiazepine receptor pharmacology, behavioral neuropharmacology, and the mechanics of CNS inhibition. Pellets allow for accurate and reproducible dosing essential for experimental consistency.

Comparative Analysis with Related Compounds

4.1 Comparison

Fluetizolam demonstrates higher potency and longer duration compared to compounds like etizolam due to unique structural modifications. It offers an important model for studying potent benzodiazepine-like receptor modulators.

4.2 Advantages for Research

Pellet forms provide reproducible dosing with minimal measurement error relative to powders. The 1 mg dose is versatile for various research applications.

Safety and Handling Guidelines

5.1 Laboratory Safety

Wear protective gloves, lab coat, and eyewear. Use in well-ventilated areas or fume hoods. Avoid inhalation or skin contact.

5.2 Disposal and Environmental Considerations

Dispose chemically waste per regulatory requirements.

5.3 Regulatory Status

Fluetizolam is a controlled research chemical and must be used in compliance with applicable laws.

Frequently Asked Questions (FAQs)

1. What is the dosage per pellet?
   1 mg of Fluetizolam.

2. What is the molecular formula?
   C17H15FN4S.

3. What solvents dissolve Fluetizolam?
   DMSO, DMF, ethanol; insoluble in PBS.

4. What receptor does it target?
   GABA-A receptor benzodiazepine sites.

5. What research is it used for?
   Benzodiazepine receptor and CNS depressant studies.

Conclusion

Fluetizolam 1 mg pellets provide a stable, high-potency benzodiazepine research tool for exploring CNS inhibitory mechanisms. Their precise dosing and purity facilitate reliable research outcomes.