HA-966 HCl Product Description

Introduction

HA-966 hydrochloride (HA-966 HCl) is a research chemical known as an antagonist at the glycine site of the NMDA receptor complex. It is a racemic compound widely studied for its neuroprotective, anticonvulsant, anxiolytic, antinociceptive, and sedative/hypnotic properties. HA-966 HCl is used in neuroscience research to explore NMDA receptor function and related neuropharmacological mechanisms.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C4H9ClN2O2

• Molecular Weight: 152.58 g/mol

• CAS Number: 42585-88-6

• Exact Mass: 152.0353

• Stereochemistry: Racemic mixture (±)

• IUPAC Name: 3-amino-1-hydroxypyrrolidin-2-one hydrochloride

Physical Characteristics

• Appearance: White to off-white crystalline powder

• Purity: Typically ≥99% research grade

• Solubility: Soluble in water and polar solvents

• Storage: Store powder at -20°C for up to 3 years; solutions stored at -80°C for best stability

Pharmacological Profile and Mechanism of Action

• HA-966 HCl acts as a glycine site antagonist at NMDA receptors, modulating glutamatergic neurotransmission non-competitively

• The R-(+)-enantiomer exhibits NMDA receptor glycine site antagonism, while the S-(–)-enantiomer has sedative and ataxic effects related to GHB-like activity

• Demonstrates neuroprotective, anticonvulsant, anxiolytic, antinociceptive, and sedative/hypnotic effects in animal research models

• Does not bind GABA-B receptors despite GHB-like effects

Research Applications

• Used in studies of glutamate receptor mechanisms and neuroprotection

• Investigates CNS disorders involving excitotoxicity, epilepsy, anxiety, and pain

• Helps in understanding glycine site function in NMDA receptor complexes

Safety and Handling

• Handle with appropriate lab PPE — gloves, goggles, lab coat

• Use in well-ventilated laboratory conditions; avoid inhalation and skin exposure

• Dispose of waste in accordance with hazardous chemical protocols

Regulatory Status

• HA-966 HCl is a research laboratory chemical, not intended for human use

• Compliance with local regulatory frameworks is mandatory

Frequently Asked Questions (FAQs)

1. What is HA-966 HCl used for?
   Neuroscientific research on NMDA receptor glycine site antagonism.

2. What is its molecular weight?
   152.58 g/mol.

3. Is HA-966 HCl soluble in water?
   Yes, it is soluble in water and polar solvents.

4. What is the stereochemistry of HA-966?
   It is a racemic mixture (±) of enantiomers with distinct pharmacological profiles.

5. How should it be stored?
   Powder: -20°C; Solution: -80°C for optimal stability.

Conclusion

HA-966 HCl is a well-characterized NMDA receptor glycine site antagonist used extensively in neuropharmacological research. Its dual enantiomer profile facilitates diverse CNS investigations focusing on neuroprotection, sedation, and anxiety.