HXE (3-HO-2′-Oxo-PCE) Product Description

Introduction

HXE, known chemically as 3-HO-2′-Oxo-PCE or Hydroxetamine, is a novel dissociative research chemical belonging to the arylcyclohexylamine class. It is structurally related to ketamine, methoxetamine (MXE), and phencyclidine (PCP), producing ketamine-like dissociative and hallucinogenic effects. HXE is utilized in neuroscience research to study NMDA receptor antagonism and dissociative mechanisms.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C14H19NO2

• Molecular Weight: 233.3 g/mol

• CAS Number: 1620054-73-0

• IUPAC Name: 2-(ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one

• Synonyms: HXE, Hydroxetamine, O-desmethyl Methoxetamine, 3-hydroxy-2-oxo-PCE

Physical Characteristics

• Appearance: White crystalline powder

• Purity: Typically ≥98% research grade

• Solubility: Soluble in ethanol and DMSO, limited aqueous solubility

• Storage: Store in a cool, dry place away from light and moisture

Pharmacological Profile and Mechanism of Action

• HXE acts as a dissociative by antagonizing NMDA receptors, particularly at the dizocilpine (MK-801) binding site

• Produces hallucinogenic and dissociative effects similar to ketamine but with a distinct potency and duration profile

• Limited human data exists; potential risks and toxicity are not fully understood

Research Applications

• Used in neuroscience and pharmacology research examining NMDA receptor function and dissociative properties

• Offers a model to study dissociative hallucinogens and their impact on CNS activity

Safety and Handling

• Use PPE: gloves, eye protection, lab coat

• Handle in well-ventilated areas or fume hoods to avoid inhalation or skin exposure

• Dispose according to hazardous chemical protocols

Regulatory Status

• Classified as a research chemical with no recognized medical use

• Usage restricted to licensed laboratories under regulatory compliance

Frequently Asked Questions (FAQs)

1. What is HXE?
   A dissociative research chemical related to ketamine and methoxetamine.

2. What effects does it produce?
   Hallucinogenic and dissociative effects via NMDA receptor antagonism.

3. What is the molecular weight?
   233.3 g/mol.

4. Is HXE soluble in water?
   Limited aqueous solubility; better dissolved in ethanol or DMSO.

5. How should it be stored?
   In a cool, dry, dark environment.

Conclusion

HXE is a novel arylcyclohexylamine dissociative research chemical valuable for studying NMDA receptor modulation and hallucinogenic mechanisms. Due to limited human data, researchers are warned to apply harm reduction and safety practices.