IDRA-21 10 mg Pellets Product Description

Introduction

IDRA-21 is a benzothiadiazine derivative and a potent positive allosteric modulator of AMPA receptors in the brain. It is known for its nootropic effects, enhancing cognition and memory by inhibiting AMPA receptor desensitization. IDRA-21 10 mg pellets provide a precise dosing form for research focused on cognitive enhancement, synaptic plasticity, and neuropharmacology.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C8H9ClN2O2S

• Molecular Weight: 232.69 g/mol

• CAS Number: 22503-72-6

• IUPAC Name: 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

• Synonyms: IDRA 21, AMPAKINE, S-18986

Physical Properties and Pellet Specifications

• Appearance: Off-white to pale yellow crystalline powder pellets

• Dosage: 10 mg per pellet

• Purity: ≥98% pharmaceutical/research grade

• Solubility: Slightly soluble in DMSO and methanol (sonicated)

• Storage: Store at room temperature in dark, inert atmosphere to maintain stability

Pharmacological Profile and Mechanism of Action

• IDRA-21 acts as a positive allosteric modulator of AMPA receptors, increasing excitatory synaptic strength by inhibiting receptor desensitization

• Enhances long-term potentiation, memory, and learning in animal models

• Crosses the blood-brain barrier effectively, with potential therapeutic applications in cognitive impairment and neurodegeneration

Research Applications

• Used in neuroscience to study cognition, synaptic plasticity, and memory enhancement

• Investigates AMPA receptor dynamics and nootropic compounds

• Provides insights into therapeutic approaches for Alzheimer’s disease, dementia, and other cognitive disorders

Safety and Handling

• Use personal protective equipment including gloves and eye protection

• Handle in a well-ventilated lab environment to avoid inhalation and skin contact

• Dispose of according to institutional hazardous chemical protocols

Regulatory Status

• For research use only; not approved for human or veterinary use

• Usage restricted to licensed laboratory settings compliant with regulatory requirements

Frequently Asked Questions (FAQs)

1. What is the dosage per pellet?
   10 mg IDRA-21 per pellet.

2. What receptor does IDRA-21 target?
   Positive allosteric modulator of AMPA glutamate receptors.

3. What are its effects?
   Cognitive enhancement, memory improvement, synaptic potentiation.

4. Is IDRA-21 soluble in water?
   Slightly soluble in DMSO and methanol; insoluble in water.

5. How should it be stored?
   Room temperature, protected from light and air in airtight containers.

Conclusion

IDRA-21 10 mg pellets offer a stable, high-purity form of a potent AMPA receptor modulator for neuroscience research. Their precise dosing and cognitive-enhancing properties make them a valuable tool in neuropharmacological and nootropic studies.