JWH-210 Product Description

Introduction

JWH-210 is a synthetic cannabinoid analgesic from the naphthoylindole family, discovered by chemist John W. Huffman. It is a potent agonist at both cannabinoid CB1 and CB2 receptors, exhibiting high binding affinity and strong cannabinoid-like effects. JWH-210 is widely used in scientific research to explore cannabinoid receptor function and synthetic cannabinoid pharmacology.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C26H27NO

• Molecular Weight: 369.5 g/mol

• CAS Number: Not standardized (JWH compounds are research chemicals)

• IUPAC Name: (4-Ethyl-1-naphthyl)-(1-pentylindol-3-yl)methanone

• Synonyms: JWH-210

Physical Properties

• Appearance: Off-white crystalline solid powder

• Purity: Typically ≥98% research grade

• Solubility: Soluble in organic solvents like ethanol and DMSO

• Storage: Stable under normal laboratory conditions when stored in dry, cool, dark environments

Pharmacological Profile and Mechanism of Action

• JWH-210 acts as a full agonist at cannabinoid CB1 and CB2 receptors, with Ki values of 0.46 nM and 0.69 nM respectively

• Produces cannabinoid-like analgesic, sedative, and psychoactive effects

• One of the most potent 4-substituted naphthoylindole cannabinoids, displaying higher affinity than JWH-122 and JWH-081

Research Applications

• Used in research to study cannabinoid receptor pharmacology and synthetic cannabinoids

• Employed in toxicological studies and forensic analysis

• Helps elucidate cannabinoid receptor-mediated physiological and toxicological effects

Safety and Handling

• Use appropriate PPE: gloves, eye protection, lab coat

• Handle in well-ventilated environments; avoid direct inhalation or skin contact

• Dispose of chemical waste according to institutional and environmental safety protocols

Regulatory Status

• Controlled or regulated in many jurisdictions as a synthetic cannabinoid

• Intended for laboratory research only; not for human consumption

Frequently Asked Questions (FAQs)

1. What is JWH-210?
   A potent synthetic cannabinoid from the naphthoylindole class acting on CB1 and CB2 receptors.

2. What effects does it have?
   Cannabinoid-like analgesic, sedative, and psychoactive effects.

3. What is the molecular weight?
   369.5 g/mol.

4. Is JWH-210 safe for human use?
   No, it is for research use only and may be neurotoxic at high doses.

5. How should it be stored?
   Store in a dry, cool, and dark place.

Conclusion

JWH-210 is a powerful cannabinoid receptor agonist valuable for research into cannabinoid pharmacology, synthetic cannabinoid toxicity, and receptor interactions. Due to its potency, it requires careful handling and strict regulatory compliance.