MDPHP Powder (Freebase) Product Description

Introduction

MDPHP (Methylenedioxypyrrolidinohexiophenone) is a synthetic cathinone stimulant chemically related to MDPV (Methylenedioxypyrovalerone). It belongs to the pyrrolidinophenone class of research chemicals, producing strong stimulant effects by acting as a norepinephrine-dopamine reuptake inhibitor (NDRI). MDPHP in freebase powder form is valued in research for studying stimulant pharmacodynamics and neurochemical interactions.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C17H23NO3

• Molecular Weight: 289.4 g/mol (freebase)

• CAS Number: 24622-61-5 (hydrochloride salt)

• Molecular Structure: Features a methylenedioxy substitution on the phenyl ring, pyrrolidine moiety, and a long hexyl side chain which contributes to its lipophilicity and potency

• Synonyms: MDPHP, 3,4-Methylenedioxypyrrolidinohexanophenone

Physical Characteristics

• Appearance: Fine crystalline powder, typically white to pale yellow

• Solubility: Poorly soluble in water; soluble in organic solvents like ethanol, DMSO, methanol

• Melting Point: Approximately 220-230°C

• Stability: Hygroscopic, sensitive to moisture and air which can cause clumping or discoloration

Pharmacological Profile and Mechanism of Action

• MDPHP acts as a potent NDRI, enhancing dopaminergic and noradrenergic transmission leading to stimulant effects

• Structurally similar to MDPV, but with a longer alkyl chain increasing its lipophilicity and potentially modifying duration and potency

• Produces effects such as increased energy, alertness, and euphoria in pharmacological models

Research and Applications

• Employed widely in synthetic cathinone research and stimulant abuse potential studies

• Used for understanding neurochemical pathways involved in psychostimulant action and neurotoxicity

• Integral to forensic toxicology and new psychoactive substance (NPS) detection studies

Safety and Handling

• Use standard PPE including gloves, goggles, and lab coat

• Avoid inhalation and direct skin contact

• Store in airtight containers in a cool, dry, and dark environment

• Follow stringent hazardous waste disposal procedures

Regulatory Status

• Research chemical for laboratory use only; not intended for human consumption

• Controlled in various jurisdictions due to stimulant and abuse potential

Frequently Asked Questions (FAQs)

1. What is MDPHP?
   A synthetic cathinone stimulant related structurally to MDPV.

2. What is the molecular weight of MDPHP freebase?
   Approximately 289.4 g/mol.

3. How soluble is MDPHP?
   Poor water solubility; soluble in organic solvents.

4. What are its primary effects?
   CNS stimulation, increased energy, and euphoria.

5. How should MDPHP powder be stored?
   In airtight containers, cool, dry, and away from light.

Conclusion

MDPHP freebase powder is a potent synthetic cathinone stimulant utilized extensively in research on stimulant pharmacology and forensic toxicology. Proper storage, handling, and regulatory compliance are critical due to its stability and abuse potential.