NM-2-AI HCl Pure Product Description

Introduction

NM-2-AI HCl (N-Methyl-2-Aminoindane Hydrochloride) is a synthetic aminoindane derivative and research chemical. It is a rigid analogue of methamphetamine with a modified structure conferring distinct pharmacological properties. NM-2-AI acts primarily as a selective norepinephrine releasing agent and reuptake inhibitor with some affinity for monoamine receptors, including adrenergic and serotonin receptors. It is used in scientific research to explore stimulant pharmacology and neurochemical effects.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C10H13N·HCl

• Molecular Weight: 183.7 g/mol

• CAS Number: 10408-85-2

• Synonyms: N-Methyl-2-Aminoindane, NM2AI, Nmethyl2Aminoindane hydrochloride

• Canonical SMILES: [H]N(C)C1CC2=CC=CC=C2C1.Cl

Physical Form and Purity

• Appearance: White to off-white crystalline powder

• Purity: ≥98% (research grade)

• Solubility: Soluble in DMF (25 mg/ml), DMSO (20 mg/ml), ethanol (3 mg/ml), and PBS pH 7.2 (10 mg/ml)

• Storage: Store at -20°C, protected from moisture and light

Pharmacological Profile and Mechanism of Action

• Selective norepinephrine releasing agent and reuptake inhibitor in vitro

• Binds to TAAR1, alpha-2A adrenergic, and serotonin receptors (5-HT1A and 5-HT2A) with moderate affinity

• It does not significantly release serotonin or dopamine at typical concentrations

• Reduces nociception and inhibits exploratory activity in animal models

Research Applications

• Neuropharmacology studies focused on norepinephrine system modulation

• Behavioral and toxicological research with aminoindane derivatives

• Analytical chemistry for substance identification and purity testing

Safety and Handling

• Use gloves, eye protection, and lab coat during handling

• Avoid inhalation and skin contact

• Store securely in airtight containers and follow hazardous waste disposal protocols

Regulatory Status

• For laboratory research use only

• Not approved for human consumption or therapeutic use

• Check local regulations as legal status varies

Frequently Asked Questions (FAQs)

1. What is NM-2-AI HCl?
   A selective norepinephrine releasing agent and aminoindane research chemical.

2. What is its molecular weight and formula?
   183.7 g/mol; molecular formula C10H13N·HCl.

3. How soluble is it?
   Soluble in DMF, DMSO, ethanol, and PBS at varying concentrations.

4. What receptors does it affect?
   TAAR1, alpha-2A adrenergic, 5-HT1A, and 5-HT2A serotonin receptors.

5. Is it safe for human use?
   No, strictly for research only.

Conclusion

NM-2-AI HCl is a potent aminoindane research chemical with selective action on norepinephrine systems and moderate activity on monoamine receptors. Proper safety and regulatory compliance are essential for use in research contexts.