Pagoclone 10 MG Pellets

PRODUCT DESCRIPTION

Introduction

Pagoclone is an anxiolytic drug belonging to the cyclopyrrolone class, structurally related to nonbenzodiazepines with effects similar to benzodiazepines but differing in chemical structure. Pagoclone is typically supplied in 10 mg pellets for research purposes. Its chemical structure comprises an isoindolone motif bound to a chlorinated naphthyridine ring system. It is designed for investigative studies into anxiolytic, sedative, and neuropharmacological properties without the full spectrum of benzodiazepine side effects.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C23H22ClN3O2C23H22ClN3O2

• Molecular Weight: 407.89 g/mol

• CAS Number: 133737-32-3

• IUPAC Name: 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-2,3-dihydro-1H-isoindol-1-one

• Synonyms: PAGOCLONE, rac-Pagoclone, IP-456, Pagoclona

Physical Properties and Purity Standards

• Appearance: Pale orange to pale red solid pellets

• Purity: Typically ≥98% pure for research-grade material

• Solubility: Slightly soluble in DMSO and methanol; low water solubility (approx. 0.00655 mg/mL)

• Storage Recommendations: Store at -20°C in a dry, dark environment to maintain stability

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Pagoclone acts as a subtype-selective agonist primarily targeting the alpha2 and alpha3 subtypes of the GABA_A receptor complex. This selective modulation results in anxiolytic and mild sedative effects without the strong sedation or dependency profile typical of classic benzodiazepines. It modulates chloride ion flow through GABA_A receptors, enhancing inhibitory neurotransmission.

Research Applications

Pagoclone is mainly investigated for its anxiolytic potential with fewer side effects compared to benzodiazepines. It is used in neuropharmacology research to explore subtype-selective GABA modulation, anxiety disorders, and cognition-related studies.

Comparative Analysis with Related Compounds

Compare to Related Compounds

Pagoclone differs from benzodiazepines by chemical family (cyclopyrrolone) and receptor subtype targeting, offering reduced sedation and addictive potential. It is related structurally to drugs like zopiclone but with different receptor subtype efficacy and clinical profile.

Advantages for Research

Selective receptor subtype agonism makes Pagoclone a valuable tool for dissecting GABAergic mechanisms involved in anxiety and sedation, helping design drugs with improved safety and efficacy profiles.

Safety and Handling Guidelines

Laboratory Safety

Handle with gloves, lab coat, and eye protection in well-ventilated laboratories. Avoid inhalation, ingestion, or direct skin contact.

Disposal and Environmental Considerations

Dispose of waste in accordance with institutional hazardous chemical disposal protocols. Avoid environmental contamination.

Regulatory Status

Pagoclone is an investigational compound not approved for general clinical use. Research distribution requires appropriate licensing.

Frequently Asked Questions (FAQs)

1. What research is Pagoclone mainly used for?
   Anxiety, GABA receptor pharmacology, and sedative mechanism studies.

2. How soluble is Pagoclone?
   Slightly soluble in DMSO and methanol; low water solubility (~0.0065 mg/mL).

3. What storage conditions are ideal for Pagoclone pellets?
   Store dry at -20°C, protected from light.

4. How does Pagoclone differ from benzodiazepines?
   Different chemical class and selective GABA_A receptor subtype targeting.

5. Are there known safety precautions?
   Standard laboratory safety procedures should be followed.

Conclusion

Pagoclone 10 MG Pellets are research-grade anxiolytic agents targeting specific GABA_A receptor subtypes. Their selective profile makes them crucial for studies seeking safer anxiolytic pharmacotherapies with reduced side effects.