Pregabalin 75 mg Capsules (56 Capsules)

PRODUCT DESCRIPTION

Introduction

Pregabalin 75 mg capsules are a pharmaceutical preparation containing the active compound pregabalin, used primarily for research into the treatment of neuropathic pain, epilepsy, generalized anxiety disorder, and fibromyalgia. The capsules contain an oral dose of 75 mg pregabalin in a solid dosage form and are designed for easy administration and precise dosing in research trials. The capsules are typically green and white with a hard gelatin shell, filled with white to off-white powder.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula: C8H17NO2C8H17NO2

• Molecular Weight: 159.23 g/mol

• CAS Number: 148553-50-8

• IUPAC Name: (S)-3-(aminomethyl)-5-methylhexanoic acid

• Synonyms: Lyrica (brand), Pregabalin BP

Physical Properties and Purity Standards

• Appearance: Hard gelatin capsules size “2,” green and white with white to off-white powder inside

• Purity: Research-grade pregabalin capsules typically contain ≥98% pure active drug

• Solubility: Soluble in water and aqueous solutions; slightly soluble in ethanol

• Storage Recommendations: Store capsules in a cool, dry place away from direct sunlight; room temperature storage recommended; avoid moisture and heat

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Pregabalin binds with high affinity to the α2δ subunit of voltage-gated calcium channels in the central nervous system, inhibiting excitatory neurotransmitter release. This action results in decreased neuronal excitability, providing anticonvulsant, analgesic, and anxiolytic effects. The compound modulates calcium influx at nerve terminals, which contributes to its efficacy against neuropathic pain and seizure disorders.

Research Applications

Used extensively in preclinical and clinical research involving neuropathic pain models, epilepsy, anxiety disorders, and fibromyalgia. Pregabalin capsules enable dose-dependent studies on pharmacokinetics, pharmacodynamics, safety, and efficacy across neurological and psychiatric indications.

Comparative Analysis with Related Compounds

Compare to Related Compounds

Pregabalin is chemically similar to gabapentin but offers increased potency, bioavailability, and a wider therapeutic window. It is distinguished by better absorption and consistent pharmacokinetics, making it preferable in many research settings.

Advantages for Research

The 75 mg capsule dosage allows flexible dose titration and ease of administration during experimental protocols. The solid dosage form enhances stability, storage convenience, and ensures accurate dosing in both clinical and preclinical trials.

Safety and Handling Guidelines

Laboratory Safety

Handle capsules with care to avoid breaking or inhalation of powder. Use gloves and avoid direct skin contact. Store securely to prevent accidental ingestion.

Disposal and Environmental Considerations

Dispose of unused capsules and packaging according to pharmaceutical waste and hazardous material regulations. Avoid direct environmental release.

Regulatory Status

Pregabalin 75 mg capsules are prescription-only across many jurisdictions and are classified as controlled substances due to potential for misuse. Research use must comply with regulatory oversight and licensing requirements.

Frequently Asked Questions (FAQs)

1. What are Pregabalin 75 mg capsules used for in research?
   Studying neuropathic pain, epilepsy, anxiety disorders, and fibromyalgia treatments.

2. How should these capsules be stored?
   In a cool, dry, light-protected environment at room temperature.

3. Are there differences compared with other strength capsules?
   Dosage strength varies from 25 mg to 300 mg allowing flexible dosing studies.

4. Is Pregabalin similar to Gabapentin?
   Yes, but Pregabalin has higher potency and more predictable pharmacokinetics.

5. What precautions should be followed in handling?
   Avoid capsule rupture and powder exposure; wear gloves; dispose properly.

Conclusion

Pregabalin 75 mg capsules contain a high-purity active ingredient formulated for research in neuropathic and neurological disorders. Their convenient dosage, stability, and pharmacological profile support detailed experimental and clinical studies.