Proscaline Fumarate

PRODUCT DESCRIPTION

Introduction

Proscaline fumarate is the fumarate salt form of proscaline, a synthetic psychedelic phenethylamine known chemically as 4-propoxy-3,5-dimethoxyphenethylamine. Proscaline is structurally related to mescaline and other psychedelic scaline derivatives. It produces psychedelic effects primarily through its agonistic activity at serotonin (5-HT2) receptors. The fumarate salt form enhances the compound’s stability and solubility, making it suitable for laboratory and pharmacological research.

Chemical Properties and Specifications

Structural and Molecular Characteristics

• Chemical Formula (Proscaline base): C13H21NO3C13H21NO3

• Molecular Weight (Proscaline base): 239.31 g/mol

• CAS Number: 39201-78-0

• IUPAC Name: 2-(3,5-Dimethoxy-4-propoxyphenyl)ethanamine

• Synonyms: Proscaline, 4-propoxy-3,5-dimethoxyphenethylamine, 4-propoxy-3,5-DMPEA

• Fumarate Salt: Proscaline fumarate (varies based on stoichiometry)

Physical Properties and Purity Standards

• Appearance: Usually white crystalline solid or powder

• Purity: Typically ≥98% for research-grade compound

• Solubility: Improved water solubility in fumarate form compared to base

• Melting Point: Approx. 170-172 °C (hydrochloride salt form, similar expected for fumarate)

• Storage Recommendations: Store in airtight containers, cool, dry conditions, protected from light

Pharmacological Profile and Mechanism of Action

Proposed Mechanism of Action

Proscaline acts as a serotonin receptor agonist, particularly targeting the 5-HT2A receptor subtype, leading to classic psychedelic effects such as altered sensory perception, enhanced cognition, and visual hallucinations. Its effects are thought to arise from this serotonergic modulation.

Research Applications

Used in research settings to understand psychedelic receptor dynamics, neuropsychopharmacology, and serotonergic system interactions. Proscaline fumarate supports investigations into therapeutic potentials of psychedelics in psychiatry.

Comparative Analysis with Related Compounds

Compare to Related Compounds

Proscaline is chemically similar to mescaline but has enhanced potency and duration. The fumarate salt form is favored in research for its improved chemical and physical stability over the free base. It sits within the scaline class of phenethylamines alongside compounds like allylescaline.

Advantages for Research

Fumarate salt facilitates handling, dissolution, and formulation, making it ideal for experimental use. Its psychedelic profile allows detailed research on serotonergic psychedelics.

Safety and Handling Guidelines

Laboratory Safety

Wear gloves, goggles, and protective clothing. Avoid inhalation or skin contact. Handle in ventilated areas.

Disposal and Environmental Considerations

Dispose of residue as per chemical hazardous waste protocols.

Regulatory Status

Proscaline fumarate is for research use only and is not approved for human consumption or clinical use.

Frequently Asked Questions (FAQs)

1. What is Proscaline fumarate used for?
   Psychedelic research and neuropharmacology targeting serotonin receptors.

2. How does fumarate salt compare to free base?
   Offers improved solubility and stability.

3. What are the storage conditions?
   Cool, dry, airtight storage away from light.

4. Is Proscaline similar to mescaline?
   Yes, but more potent and longer-lasting.

5. Are there safety concerns?
   Follow standard lab safety guidelines.

Conclusion

Proscaline fumarate is a high-purity psychedelic research chemical with enhanced physical and chemical properties. It serves as an important tool for studying serotonergic psychedelics and their therapeutic potentials under controlled research conditions.